Actively Recruiting
Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS
Led by Sanatorio Anchorena San Martin · Updated on 2026-04-16
30
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spontaneous breathing during the transition from controlled to assisted ventilation in ARDS may be harmful, as high respiratory drive can generate large transpulmonary pressure swings and worsen lung injury. Higher PEEP may mitigate this by reducing inspiratory effort and lung stress, but patient response is variable and difficult to predict. While improved lung compliance appears to mediate the protective effects of PEEP, its bedside assessment is complex. Preclinical data suggest that changes in compliance are inversely reflected by changes in respiratory rate, but this relationship and its clinical utility in ARDS patients remain unclear.
CONDITIONS
Official Title
Prediction of Inspiratory Effort Response to High PEEP in Patients Recovering From ARDS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Need of invasive mechanical ventilation
- Patients who had fulfill ARDS criteria based on Berlin definition during any time of invasive mechanical ventilation
- Patient ventilated in pressure support ventilation
- Time of invasive ventilation expected to be longer than 24 hs after the day of enrollment
You will not qualify if you...
- Neuromuscular diseases (e.g., amyotrophic lateral sclerosis, Duchenne Erb)
- Previous diagnosis of chronic obstructed pulmonary disease
- Not resolved pneumothorax
- Bronchopleural fistula
- Suspicion of central respiratory drive alteration (e.g., benzodiazepines intoxication)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sanatorio Anchorena de San Martin
San Martín, Buenos Aires, Argentina, B1650CQU
Actively Recruiting
Research Team
J
Joaquin Pérez, PT
CONTACT
J
Javier H Dorado, PT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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