Actively Recruiting
Prediction Model for MINS After Major Hepatobiliary Surgery
Led by Beijing Tsinghua Chang Gung Hospital · Updated on 2026-01-12
1800
Participants Needed
6
Research Sites
107 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.
CONDITIONS
Official Title
Prediction Model for MINS After Major Hepatobiliary Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 85 years with ASA physical status II-III
- Undergoing major hepatobiliary surgery lasting 3 hours or more, including hepatectomy of 3 or more segments or biliary reconstruction
- Surgery requiring intensive care unit admission postoperatively
- Availability of paired perioperative high-sensitivity cardiac troponin T (hs-cTnT) data
- Complete documentation of surgical details such as surgical approach, resection type, number of segments removed, tumor size and location, and presence of cirrhosis
You will not qualify if you...
- History of acute myocardial infarction, unstable angina, heart failure, or chronic kidney disease with eGFR less than 60 ml/min/1.73 m² before surgery
- Missing data on hepatic inflow occlusion strategy
- Missing important surgical or clinical data that cannot be imputed
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University
Beijing, China
Actively Recruiting
2
Peking University International Hospital
Beijing, China
Not Yet Recruiting
3
The First Affiliated Hospital of Army Medical University
Chongqing, China
Not Yet Recruiting
4
Qingdao West Coast New Area People's Hospital
Qingdao, China
Not Yet Recruiting
5
The First Affiliated Hospital of Shandong First Medical University
Shandong, China
Not Yet Recruiting
6
Zhuhai People's Hospital
Zhuhai, China
Not Yet Recruiting
Research Team
Z
Zhifeng Gao, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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