Actively Recruiting
Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study
Led by Shanghai Geriatric Medical Center · Updated on 2026-03-19
634
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective cohort study aiming to construct a prediction model for postoperative cognitive dysfunction (POCD) in elderly cardiac patients. We plan to enroll elderly patients aged ≥65 years undergoing cardiac surgery. Peripheral blood samples and functional magnetic resonance imaging (fMRI) data will be collected at baseline and key time points post-surgery. The primary objectives are to identify novel peripheral blood protein biomarkers for POCD, explore the correlation between fMRI characteristics and POCD, and establish a reliable early prediction model to improve perioperative management and reduce the incidence of POCD in elderly cardiac surgical patients.
CONDITIONS
Official Title
Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects aged 65 years or older, any gender
- Indicated for cardiac surgery with cardiopulmonary bypass
- Normal liver and kidney function during screening
- No active infection during screening
- Able to cooperate with MMSE and MoCA cognitive assessments
- Signed informed consent form
You will not qualify if you...
- Conditions that may interfere with study results as judged by investigator
- Active liver disease or chronic hepatitis B or C within 1 month
- Active systemic infection requiring antibiotics within 1 week before surgery
- Low preoperative MMSE score based on education level thresholds
- Obesity (BMI 30 kg/m² or higher)
- Uncontrolled hypertension (systolic ≥180 mmHg or diastolic ≥100 mmHg)
- History of organ transplantation including corneal
- Clinically significant uncontrolled respiratory diseases
- Diagnosed or suspected demyelinating diseases
- Use of glucocorticoids or immunosuppressive drugs
- Diseases significantly affecting the nervous system
- Participation in other clinical trials
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Geriatric Medical Center
Shanghai, China
Actively Recruiting
Research Team
H
Hao Fang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here