Actively Recruiting

Age: 18Years +
All Genders
NCT04574037

Prediction of Post-stroke Motor Recovery

Led by Assistance Publique - Hôpitaux de Paris · Updated on 2024-02-05

200

Participants Needed

1

Research Sites

336 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The prediction of motor recovery in the acute phase of stroke is crucial for several clinical reasons: (i) informing the patient and his relatives, (ii) helping to identify the patient's endorsement (return home or rehabilitation) as well as the adaptation of the rehabilitation program to what can be expected from it. To date, an algorithm (decision tree) proposed by C. Stinear's team named PREP2 is the best predictive tool with 75% of patients well classified at 3 months. It predicts the functional recovery of the upper limb after stroke 3 months before the episode by categorizing recovery as "excellent", "good", "limited" as well as "minor" (poor). With two data (SAFE score, age) or three (SAFE score, Motor evoked potential, NIHSS), the prediction is effective three times out of 4. In the study the team is proposing "PREP-UCV", it would like to validate this algorithm as it is with patients in the active file who are victims of stroke. The expected accuracy is 75% or more. As a secondary objective, the team would like to confirm that it find the same algorithm starting from the initial data from PREP 2 (side of the stroke, type of stroke (ischemic and / or hemorrhagic), involvement of the corticospinal tract on MRI, sex at birth ) as well as two other factors which are also very important: cognitive status (dysexecutive / aphasia / neglect), as well as the neutrophils on lymphocytes ratio.

CONDITIONS

Official Title

Prediction of Post-stroke Motor Recovery

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Admitted in the Pitié-Salpêtrière stroke unit
  • Stroke with an upper limb motor deficit
  • Agree to participate
Not Eligible

You will not qualify if you...

  • Contraindication to MRI or transcranial magnetic stimulation (TMS)
  • Under legal guardianship
  • No healthcare insurance

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Service des Urgences Cérébro-Vasculaires, Hôpital Pitié Salpêtrière

Paris, France, 75013

Actively Recruiting

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Research Team

C

Charlotte ROSSO, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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