Actively Recruiting
Predictive Biomarker for Endoscopic Therapy in Chronic Pancreatitis
Led by NYU Langone Health · Updated on 2025-12-17
100
Participants Needed
1
Research Sites
235 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is an observational prospective study to develop predictive biomarkers for pain response in participants with chronic pancreatitis scheduled for endoscopic therapy. Participants will undergo baseline assessments including electroencephalography (EEG), quantitative sensory testing (QST), and psychosocial questionnaires. Response to endoscopic therapy will be assessed at approximately 3, 6, 12 and 18 months post-procedure using questionnaires.
CONDITIONS
Official Title
Predictive Biomarker for Endoscopic Therapy in Chronic Pancreatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults older than 18 years
- Diagnosis of chronic pancreatitis based on Cambridge III or IV criteria or M-ANNHEIM criteria for definitive chronic pancreatitis
- Scheduled for endoscopic therapy for ductal obstruction as part of routine clinical care
- Pain present at least 3 days per week for 3 months or longer
- Average pain over the last week is 4 or higher on an 11-point numeric rating scale
You will not qualify if you...
- Chronic pain syndrome other than chronic pancreatitis
- Episode of acute pancreatitis within 2 months before enrollment
- Endoscopic therapy or pancreatic surgery within 6 months before enrollment
- Active illicit drug use (marijuana use allowed)
- American Society of Anesthesiologists classification higher than 3
- Immune-mediated pancreatitis or pancreatic tumors
- Major neurological diseases such as stroke, uncontrolled epilepsy, or dementia
- Diagnosis of schizophrenia
- Chronic benzodiazepine use (short-acting use allowed if benzodiazepine can be held before EEG)
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
Research Team
L
Lisa Doan, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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