Factors Predicting Loss of Functional Independence in Adults With Alzheimers Disease or Related Memory Disorders in a Regional Real-World Study

What this Trial Is About

Alzheimers disease and related disorders ADRD are disabling conditions characterized by cognitive decline, loss of independence, and behavioral changes. Without a current cure, this study aims to identify factors that predict how patients ability to function changes over time. The research involves building a regional database of medical records from patients in the Auvergne Rhone-Alpes region of France to better understand disease progression. Participants are patients with memory complaints or neurocognitive disorders who undergo medical examinations at memory centers. The study follows about 5400 patients over a maximum of 10 years, with evaluations every 6 to 12 months. These assessments measure functional autonomy and include tests like IADL, DAD6, New AGGIR, NPI, and mini-Zarit to evaluate independence, behavior, and caregiver burden. During the study, patients receive standard medical care and extensive evaluations at regular intervals. Researchers track changes in each patients functional autonomy over time as the main outcome. The study began in September 2020 and will continue until March 2032, allowing long-term observation of disease progression and its impact on daily living.

Predictive Factors of Autonomy Loss in Real-life Cohort