Using Early Lung Ultrasound to Predict Breathing Problems in Late Preterm Babies Born Between 34 and 36 Weeks
Led by Hackensack Meridian Health · Updated on 2026-05-22
300
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Respiratory problems are a major challenge for newborns, especially late-preterm infants born between 34 and 36 weeks gestation. These infants face risks similar to more premature babies but may not always be born in hospitals with specialized neonatal care. This research aims to evaluate the usefulness of early point-of-care lung ultrasound LUS in predicting respiratory difficulties within the first 48 hours of life in these late-preterm newborns. It also compares the accuracy of three different lung ultrasound scoring systems to see which best predicts respiratory problems.
In this observational study, babies born late-preterm who are initially breathing room air or receiving low-flow oxygen through a nasal cannula will receive a lung ultrasound within their first 4 hours of life. The ultrasound images will be scored using three established scoring methods. The babies will be monitored during their hospital stay to watch for any signs of respiratory distress or need for increased respiratory support during the first 48 hours after birth.
Participants will be followed closely in the neonatal intensive care unit or well-baby nursery to track the onset and severity of breathing difficulties, including how soon respiratory support is needed and how long it is required. Researchers will use these observations to assess how well the lung ultrasound scores predict respiratory worsening. The study will also look at the need for invasive respiratory support and the timing of respiratory distress signs. The trial will continue through the initial hospital stay, aiming to improve early identification of at-risk late-preterm infants.
CONDITIONS
Brief Title
Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates
Research Team
J
Jeanette Haugh
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Inborn infants born between 34 weeks 0 days and 36 weeks 6 days gestational age
Infants breathing room air or receiving up to 1 litre per minute oxygen by nasal cannula
Admitted to the Neonatal Intensive Care Unit or Well Baby Nursery
You will not qualify if you...
Infants born before 34 weeks or after 36 weeks 6 days gestation
Major genetic anomaly or syndromic condition
Cardiac or pulmonary structural defects
Cord pH less than 7.0 or 5-minute APGAR score of 5 or less
Suspected fetal hemorrhage or other significant anemia at birth
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Within the first 4 hours of life
Participants undergo point-of-care lung ultrasound within the first 4 hours of life to assess lung status using three established scoring systems.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 48 hours
Participants are monitored during initial hospitalization for respiratory decompensation and need for respiratory support within the first 48 hours of life.
Continuous monitoring during hospitalization
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Published Research Related To This Trial
Lung ultrasound features predict admission to the neonatal intensive care unit in infants with transient neonatal tachypnoea or respiratory distress syndrome born by caesarean section.
Antonio Poerio, Silvia Galletti, Michelangelo Baldazzi...