Actively Recruiting

Age: 34Weeks - 36Weeks
All Genders
ID07216053

Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates

Led by Hackensack Meridian Health · Updated on 2026-05-22

300

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Respiratory problems are a major challenge for newborns, especially late-preterm infants born between 34 and 36 weeks gestation. These infants face risks similar to more premature babies but may not always be born in hospitals with specialized neonatal care. This research aims to evaluate the usefulness of early point-of-care lung ultrasound (LUS) in predicting respiratory difficulties within the first 48 hours of life in these late-preterm newborns. It also compares the accuracy of three different lung ultrasound scoring systems to see which best predicts respiratory problems. In this observational study, babies born late-preterm who are initially breathing room air or receiving low-flow oxygen through a nasal cannula will receive a lung ultrasound within their first 4 hours of life. The ultrasound images will be scored using three established scoring methods. The babies will be monitored during their hospital stay to watch for any signs of respiratory distress or need for increased respiratory support during the first 48 hours after birth. Participants will be followed closely in the neonatal intensive care unit or well-baby nursery to track the onset and severity of breathing difficulties, including how soon respiratory support is needed and how long it is required. Researchers will use these observations to assess how well the lung ultrasound scores predict respiratory worsening. The study will also look at the need for invasive respiratory support and the timing of respiratory distress signs. The trial will continue through the initial hospital stay, aiming to improve early identification of at-risk late-preterm infants.

CONDITIONS

Brief Title

Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates

Who Can Participate

Age: 34Weeks - 36Weeks
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Inborn infants born between 34 weeks 0 days and 36 weeks 6 days gestational age
  • Infants breathing room air or receiving up to 1 litre per minute oxygen by nasal cannula
  • Admitted to the Neonatal Intensive Care Unit or Well Baby Nursery
Not Eligible

You will not qualify if you...

  • Infants born before 34 weeks or after 36 weeks 6 days gestation
  • Major genetic anomaly or syndromic condition
  • Cardiac or pulmonary structural defects
  • Cord pH less than 7.0 or 5-minute APGAR score of 5 or less
  • Suspected fetal hemorrhage or other significant anemia at birth

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Within the first 4 hours of life

Participants undergo point-of-care lung ultrasound within the first 4 hours of life to assess lung status using three established scoring systems.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 48 hours

Participants are monitored during initial hospitalization for respiratory decompensation and need for respiratory support within the first 48 hours of life.

Continuous monitoring during hospitalization

Trial Site Locations

Total: 1 location

1

Hackensack Univeristy Medical Center

Hackensack, New Jersey, United States, 07601

Actively Recruiting

Loading map...

Research Team

J

Jeanette Haugh

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

Similar Trials

Admission to the Kangaroo Mother Care Ward and Maternal Post...

Low Birth Weight

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Lung ultrasound features predict admission to the neonatal intensive care unit in infants with transient neonatal tachypnoea or respiratory distress syndrome born by caesarean section.

Antonio Poerio, Silvia Galletti, Michelangelo Baldazzi...

https://pubmed.ncbi.nlm.nih.gov/32949291

Ultrasound performed shortly after birth can predict the respiratory support needs of late preterm and term infants: A diagnostic accuracy study.

Guannan Xi, Jiale Dai, Xuefeng Wang...

https://pubmed.ncbi.nlm.nih.gov/33768734

Lung Ultrasonography Score to Evaluate Oxygenation and Surfactant Need in Neonates Treated With Continuous Positive Airway Pressure.

Roselyne Brat, Nadya Yousef, Roman Klifa...

https://pubmed.ncbi.nlm.nih.gov/26237465

Lung Ultrasound in Neonates: A Narrative Review Along With Diagnostic Insights and Early Postnatal Applications.

Salvatore Michele Carnazzo, Stergios Nasikas, Francesco F Comisi

https://pubmed.ncbi.nlm.nih.gov/39479113