Actively Recruiting
Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome
Led by University Hospital, Lille · Updated on 2025-08-24
200
Participants Needed
1
Research Sites
154 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Lille
Lead Sponsor
R
Région Nord-Pas de Calais, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Optic neuritis (ON) represents around 30% of clinical presentation of clinically isolated syndrome (CIS). Asymptomatic optic nerve involvement is very frequent in all stage of multiple sclerosis (MS) disease including the CIS. However, optic nerve is still not part of MS diagnosis criteria. The main objective of our regional and multicenter study is to evaluate the prognostic value of optic nerve involvement at the earliest clinical stage of MS (=CIS) for the diagnosis of clinically definite MS (2nd clinical relapse) and the delay until the 2nd relapse.
CONDITIONS
Official Title
Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients between 18 and 55 years old
- Occurrence of clinically isolated syndrome (CIS) within 6 months
- Presence of two T2 hypersignals on brain or spinal cord MRI suggestive of multiple sclerosis or presence of oligoclonal bands
- Able and willing to provide written informed consent
You will not qualify if you...
- Presence of eye conditions that could affect optic nerve MRI or retinal OCT, such as diabetes mellitus, glaucoma, retinopathy, or ametropia greater than 6 diopters
- History of multiple sclerosis relapses
- Extensive myelitis longer than 3 vertebral bodies
- Bilateral optic neuritis without T2 lesions suggestive of multiple sclerosis
- Contraindications to MRI or gadolinium injection
- Pregnancy or breastfeeding
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital Roger Salengro
Lille, France, 59037
Actively Recruiting
Research Team
J
Juliette Bochu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here