Actively Recruiting
Predictors of Long-Term Evolution in Long COVID; 4-Year Follow-Up. (BioICOPER Follow-up Study)
Led by Instituto de Investigación Biomédica de Salamanca · Updated on 2026-03-12
400
Participants Needed
1
Research Sites
172 weeks
Total Duration
On this page
Sponsors
I
Instituto de Investigación Biomédica de Salamanca
Lead Sponsor
C
Carlos III Health Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Long COVID (persistent COVID) represents a major global health challenge due to its high prevalence (approximately 7%), significant impact on quality of life, and socioeconomic burden. Despite extensive research, diagnostic tools to objectively identify or predict long COVID evolution are still lacking. The BioICOPER Follow-up Study aims to analyze the influence of biomarker evolution on clinical symptomatology (particularly chronic fatigue) and vascular health after four years of follow-up among 400 participants previously included in the original BioICOPER cohort. Advanced proteomic analysis, vascular function assessment, and machine-learning-based predictive modeling will be used to identify biomarkers associated with disease progression, stratified by sex. This project will contribute to personalized clinical management of long COVID and improved diagnostic and therapeutic strategies in primary care.
CONDITIONS
Official Title
Predictors of Long-Term Evolution in Long COVID; 4-Year Follow-Up. (BioICOPER Follow-up Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old or older
- Confirmed previous SARS-CoV-2 infection
- Diagnosis of long COVID according to WHO criteria
- Participation in the baseline BioICOPER study
- Signed informed consent for re-evaluation
You will not qualify if you...
- Acute illness preventing participation
- Cognitive or physical impairment limiting data collection
- Withdrawal of informed consent
- Age under 18 years old
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Av. de Portugal 83. Planta 2
Salamanca, Salamanca, Spain, 37005
Actively Recruiting
Research Team
M
Manuel Angel Gómez Marcos, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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