Actively Recruiting
Predictors of Post-COVID Clinical and Cognitive Consequences
Led by VA Office of Research and Development · Updated on 2026-01-23
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
J
John D. Dingell VA Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying the long-term physical and mental health effects experienced by some people after COVID-19 infection, known as Post-acute Sequelae of SARS-COV-2 infection (PASC). This research focuses on whether sleep disturbances and the severity of sleep apnea play a role in these ongoing symptoms, including fatigue and cognitive problems. The study aims to gather preliminary data on how sleep quality and duration relate to post-COVID fatigue and cognitive function, as well as explore the impact of inflammatory markers and vaccination status on long-COVID symptoms. The study is observational and includes two groups: patients with both PASC and obstructive sleep apnea (OSA), and patients with OSA but no history of COVID-19. Researchers will collect data retrospectively and prospectively to examine sleep patterns, severity of sleep apnea, and adherence to positive airway pressure (PAP) therapy. They will also evaluate how these factors influence fatigue, cognitive function, and quality of life over time. Participants will be assessed at baseline and followed for changes over three months, including various neurocognitive tests, sleep quality and sleepiness questionnaires, fatigue severity measures, and exercise capacity tests such as the six-minute walk test. The study will monitor sleep disturbances and cognitive outcomes to better understand their relationship with long-COVID. Data collection will include biomarker levels and vaccination history to explore their effects on symptoms and recovery.
CONDITIONS
Brief Title
Predictors of Post-COVID-19 Clinical and Cognitive Consequences
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals 18 years or older with a prior diagnosis of COVID-19 infection
- Both males and females of all racial and ethnic groups
- Patients with obstructive sleep apnea confirmed by apnea hypopnea index of 5/hour on sleep study, with or without history of COVID-19 infection
You will not qualify if you...
- Unable to give informed consent
- Active suicidal symptoms
- Children of all ages
- Pregnant women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline assessments
Participants undergo assessments to evaluate sleep disturbances, cognitive function, and biomarker levels related to post-COVID conditions.
1 baseline visit (in-person)
Duration - 3 months
Participants are monitored to assess changes in fatigue, sleep quality, cognitive function, and quality of life over time after recovery from SARS-CoV-2 infection.
1 follow-up visit at 3 months (in-person)
Trial Site Locations
Total: 1 location
1
John D. Dingell VA Medical Center, Detroit, MI
Detroit, Michigan, United States, 48201-1916
Actively Recruiting
Research Team
R
Ruchi Rastogi, MS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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