Predictors of Early Relapse During Follow-up of Remitted Major Depression A Study Observing Clinical, Activity, Sleep, Cognitive, and Brain Features to Forecast Relapse

What this Trial Is About

Major Depressive Disorder (MDD) is a common condition characterized by recurring episodes of depression. One challenge for people with MDD is that depressive episodes often come back even after treatment. This research aims to monitor various features such as symptoms, physical activity, sleep, thinking abilities, and brain activity to better understand how and why relapses happen. The study will help develop a tool to predict who might relapse and when, which could improve monitoring and prevention of future episodes. The study is a naturalistic observational cohort conducted across nine Canadian clinical sites. Participants will be followed for 18 months after enrollment. They will wear a wrist device called the GENEActiv accelerometer to track movement during the entire study. Weekly self-assessments of depression and anxiety symptoms will be completed using the QIDS-16SR and GAD-7 questionnaires. Every two months, participants will have in-person visits to measure depression severity with the MADRS scale. Speech samples and brain activity recordings using EEG will be collected every two months and if relapse occurs. Participants will be involved in regular symptom rating and physical activity monitoring throughout the 18-month period. Researchers will collect and analyze data on depression symptoms, anxiety, speech, and brain function to understand relapse mechanisms. The main outcome measured is the time until relapse within 18 months. This study aims to provide meaningful insights to help healthcare providers identify early signs of relapse and improve care for individuals with MDD.

Predictors of Relapse in Major Depressive Disorder