Actively Recruiting
Prednisone for CRPS in Distal Radius Fracture
Led by University of British Columbia · Updated on 2026-05-01
40
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
Sponsors
U
University of British Columbia
Lead Sponsor
C
Canadian Orthopaedic Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Wrist fractures are the most prevalent adult fracture. Complex regional pain syndrome (CRPS) is a common complication that can occur, leading to permanent disability and is costly to the patient and healthcare system. In addition, amidst the opioid epidemic, the risk of increased opioid use in patients with CRPS prompts the need to find viable treatment strategies. This study aims to evaluate an anti-inflammatory medication, prednisone, in the early treatment of CRPS. Patients with wrist fractures who undergo surgical treatment will be randomized to receiving placebo vs prednisone for 2 weeks. Clinical assessments in the follow up period will be compared.
CONDITIONS
Official Title
Prednisone for CRPS in Distal Radius Fracture
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is aged 19 years or older
- Patient has a unilateral, closed, distal radius fracture confirmed by radiographs
- The fracture is acute, within 21 days of injury
- Patient undergoes open reduction internal fixation with volar locking plate
- Patient is identified as at risk of developing CRPS with 2 or more of the following: pain score on visual analogue scale (VAS) �3e= 5/10 within 1 week of injury and beyond; Centre of Epidemiologic Studies Depression (CES-D) score �3e= 16; patient identifies as female
- Patient is identified as developing signs of CRPS based on the Budapest CRPS Criteria
- Patient provides informed consent
You will not qualify if you...
- Patient has previously fractured ipsilateral wrist
- Patient has neurovascular injury associated with distal radius fracture
- Patient has associated extremity or polytrauma injuries interfering with rehabilitation and outcome measurements
- Patient has allergy to prednisone or placebo ingredients
- Patient has contraindication to prednisone or placebo ingredients
- Patient already takes a glucocorticoid medication
- Patient has active bacterial, viral, or fungal infection
- Patient is diagnosed with diabetes
- Patient is pregnant, planning on becoming pregnant, or breastfeeding
- Patient is anticipated to have difficulty completing study follow up
AI-Screening
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Trial Site Locations
Total: 1 location
1
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
Research Team
D
David Stockton, MD, MASc, FRCSC
CONTACT
A
Alice (Wei Ting) Wang, MSc, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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