Actively Recruiting

Phase Not Applicable
Age: 18Years +
FEMALE
NCT07199283

The PreEclampsia Postpartum Prevention Trial

Led by Karolinska Institutet · Updated on 2026-05-04

356

Participants Needed

2

Research Sites

101 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy. The main questions it aims to answer are: * Does the 9-month intervention reduce systolic and diastolic blood pressure? * Does the intervention promote postpartum weight loss? * Does the intervention affect weight and blood pressure depending on early pregnancy BMI? Researchers will compare the bundle intervention to standard care to see if the intervention improves cardiometabolic health and lifestyle outcomes. All participants will attend clinical visits for outcome assessments. Participants in the intervention group will: * Receive online targeted screening and group meetings with study personnel * Use the trial-specific PEPP app to access self-monitoring tools for blood pressure and weight, lifestyle modification, and health education * Follow the intervention in two phases: starting after inclusion (≈8 weeks postpartum) with a Light phase (baseline-3 months) and progressing to an Intensive phase (3-9 months)

CONDITIONS

Official Title

The PreEclampsia Postpartum Prevention Trial

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • First-time mothers postpartum
  • Diagnosis of preeclampsia during the first pregnancy
  • Age 18 years or older
  • Singleton live birth with infant still alive
  • Ability to understand and speak Swedish or English
  • Ownership of a smartphone (Android or iOS)
  • Ability to provide informed consent
Not Eligible

You will not qualify if you...

  • Pre-pregnancy hypertension
  • Diabetes mellitus type I or II
  • Cardiovascular disease
  • Kidney disease
  • Systemic lupus erythematosus
  • Antiphospholipid syndrome
  • Previous or current eating disorders
  • Ongoing new pregnancy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Karolinska University Hospital

Stockholm, Stockholm County, Sweden, 17176

Actively Recruiting

2

Karolinska Institutet

Stockholm, Stockholm County, Sweden, 17177

Actively Recruiting

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Research Team

K

Kari Johansson, PhD

CONTACT

A

Anna Sandström, PhD, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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