Actively Recruiting
The PreEclampsia Postpartum Prevention Trial
Led by Karolinska Institutet · Updated on 2026-05-04
356
Participants Needed
2
Research Sites
101 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy. The main questions it aims to answer are: * Does the 9-month intervention reduce systolic and diastolic blood pressure? * Does the intervention promote postpartum weight loss? * Does the intervention affect weight and blood pressure depending on early pregnancy BMI? Researchers will compare the bundle intervention to standard care to see if the intervention improves cardiometabolic health and lifestyle outcomes. All participants will attend clinical visits for outcome assessments. Participants in the intervention group will: * Receive online targeted screening and group meetings with study personnel * Use the trial-specific PEPP app to access self-monitoring tools for blood pressure and weight, lifestyle modification, and health education * Follow the intervention in two phases: starting after inclusion (≈8 weeks postpartum) with a Light phase (baseline-3 months) and progressing to an Intensive phase (3-9 months)
CONDITIONS
Official Title
The PreEclampsia Postpartum Prevention Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- First-time mothers postpartum
- Diagnosis of preeclampsia during the first pregnancy
- Age 18 years or older
- Singleton live birth with infant still alive
- Ability to understand and speak Swedish or English
- Ownership of a smartphone (Android or iOS)
- Ability to provide informed consent
You will not qualify if you...
- Pre-pregnancy hypertension
- Diabetes mellitus type I or II
- Cardiovascular disease
- Kidney disease
- Systemic lupus erythematosus
- Antiphospholipid syndrome
- Previous or current eating disorders
- Ongoing new pregnancy
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Karolinska University Hospital
Stockholm, Stockholm County, Sweden, 17176
Actively Recruiting
2
Karolinska Institutet
Stockholm, Stockholm County, Sweden, 17177
Actively Recruiting
Research Team
K
Kari Johansson, PhD
CONTACT
A
Anna Sandström, PhD, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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