Actively Recruiting
Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft
Led by Marquette University · Updated on 2024-09-27
50
Participants Needed
1
Research Sites
162 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery. The primary question it aims to answer is: • Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo? Secondary questions are: * Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo? * Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?
CONDITIONS
Official Title
Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age >18 years
- Good general health (controlled conditions)
- Fluent in English
- Treatment-planned for single site extraction and bone graft surgery
You will not qualify if you...
- Pregnancy
- Site with active infection such as pus or abscess
- Experiencing pain before surgery
- Oral surgery at more than one site or quadrant in the same session
- Surgery performed under sedation
- Contraindications for oral bone grafting surgery (e.g., on anticoagulants, medication-related osteonecrosis of the jaw)
- Acute or chronic oral pain from conditions or previous treatments
- Diseases or medications affecting wound healing, like poorly controlled diabetes, bisphosphonate use, corticosteroids, chemotherapy, or immunosuppressive therapy
- Current or chronic use (≥4 weeks) of anti-inflammatory, analgesic, corticosteroid, or sedative medications in the past 6 months
- Health conditions preventing NSAID use, such as stomach ulcers, bleeding disorders, kidney or liver disease
- Medications that interact with NSAIDs, including anticoagulants, ACE inhibitors, or diuretics
- Allergy to ibuprofen, acetaminophen, aspirin, or study materials
- Consuming 3 or more alcoholic drinks daily
- Planned heart surgery or heart surgery within the last 6 months
- Not fluent in English
AI-Screening
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Trial Site Locations
Total: 1 location
1
Marquette University School of Dentistry Graduate Periodontics Clinic
Milwaukee, Wisconsin, United States, 53233
Actively Recruiting
Research Team
V
Vrisiis Kofina, DDS, MS
CONTACT
C
Christos Gousias, DDS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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