Transfer of Aneuploid or Mosaic Embryos Following Preimplantation Genetic Testing

What this Trial Is About

This research aims to understand how often embryos reported as abnormal through preimplantation genetic testing lead to live births. It also evaluates whether pregnancies from these embryos face higher risks of complications and if the children have increased risks for health or developmental issues during their first five years. The study focuses on patients undergoing embryo transfers, comparing outcomes between those receiving non-euploid (aneuploid or mosaic) embryos and those receiving euploid embryos. Participants are grouped based on the type of embryo transferred. One group includes patients who choose to transfer non-euploid embryos when no acceptable euploid embryos are available, and the other group includes those undergoing euploid embryo transfer following standard care protocols. All other medical interventions follow usual care practices. The study gathers genetic testing results and records pregnancy outcomes over several years. Participants provide medical records related to their pregnancy, and any genetic or fetal testing data are carefully reviewed. For those with live births, pediatric records and developmental milestone surveys are collected for up to five years to assess child health and development. The primary outcome is pregnancy rate within three years, with additional outcomes including live birth rate, obstetric complications, and pediatric development tracked over extended timeframes. There is no financial compensation for participation.

Pregnancy and Developmental Outcomes After Transfer of Reportedly Aneuploid or Mosaic Embryos