Effectiveness of Individualized Prehabilitation With Exercise and Nutrition Support for Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation for Blood Cancer

What this Trial Is About

Researchers are studying adults diagnosed with blood cancer who are scheduled to receive allogeneic hematopoietic stem cell transplantation, an intensive treatment associated with long hospital stays and muscle weakness. The trial aims to evaluate whether an individualized prehabilitation program combined with usual care improves health-related quality of life compared to usual care alone. This trial is a national randomized controlled study assessing the effects of exercise and nutrition before transplantation, addressing common challenges like muscle dysfunction and fatigue in this population. Participants are randomly assigned to one of two groups. The usual care group receives standard treatment including physical and occupational therapy during hospitalization and possible rehabilitation referrals afterward. The experimental group receives usual care plus supervised, personalized resistance training three times per week and optimized nutritional support with tailored dietary counseling and supplements. The intervention starts at least four weeks before transplantation. During the study, participants undergo assessments from enrollment to 90 days after transplantation. Researchers measure health-related quality of life using a cancer-specific questionnaire, the duration of hospitalization, muscle mass and strength, including hand grip and lower limb function. The study includes muscle function tests and tracks outcomes to understand the interventions impact on recovery and well-being after transplantation.

Prehabilitation for Patients Diagnosed With Blood Cancer and Treated With Al-logeneic Hematopoietic Stem Cell Transplantation