Cardio-Oncology Prehabilitation Program to Improve Heart Health in Adults at High Risk Undergoing Hematopoietic Stem Cell Transplant

What this Trial Is About

Researchers are evaluating a Cardio-Oncology Prehabilitation program designed for patients at high risk of cardiovascular events who are preparing to undergo Hematopoietic Stem Cell Transplantation HSCT. The study aims to assess the feasibility and early effectiveness of this program in improving cardiorespiratory fitness and reducing acute cardiovascular complications in these patients. The program involves a multimodal approach including an individualized exercise plan based on a detailed cardiovascular assessment and medical management of cardiovascular risk factors. This intervention is delivered over an 8-week period at home, starting with an initial cardiovascular evaluation and concluding with a follow-up assessment before HSCT. Participants will be engaged in personalized exercise sessions monitored for adherence and effectiveness. Researchers will measure outcomes such as recruitment and retention rates, adherence to the program, changes in cardiorespiratory fitness markers like anaerobic threshold and VO2peak, symptom scores, quality of life, and biomarkers. The study duration for each participant is 8 weeks post enrollment, with safety and feasibility outcomes carefully tracked throughout.

Prehabilitation Program to Improve Cardiac Reserve in High-Risk Patients Undergoing Hematopoietic Stem Cell Transplantation