Actively Recruiting
Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial
Led by Dana-Farber Cancer Institute · Updated on 2026-04-14
30
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
Sponsors
D
Dana-Farber Cancer Institute
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to examine the feasibility and effects of 12-week exercise training at different intensities among individuals with advanced lung cancer receiving immune checkpoint inhibitors. The names of the study interventions involved in this study are:
CONDITIONS
Official Title
Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Diagnosed with non-small cell lung cancer (NSCLC)
- Receiving anti-PD-1 or anti-PD-L1 antibody treatment for at least one month with plans to continue for at least 12 weeks
- Medical clearance from treating oncologist to perform exercise and testing
- No uncontrolled medical conditions that could worsen with exercise
- Able to communicate and complete forms in English
- Doing 60 minutes or less of moderate-to-vigorous aerobic exercise per week in the past month
- Willing to sign informed consent before study procedures
- Willing to travel to Dana-Farber Cancer Institute for data collection
You will not qualify if you...
- Doing more than 60 minutes of moderate-to-vigorous aerobic exercise per week in the past month
- Unstable medical conditions that prevent moderate-to-vigorous exercise
- Unable to comply with study safety monitoring requirements
- Having a second cancer requiring treatment that would interfere with this study (except certain skin cancers)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
C
Christina Dieli-Conwright, PhD, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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