Actively Recruiting
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
Led by Massachusetts General Hospital · Updated on 2026-02-27
80
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.
CONDITIONS
Official Title
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 2 18 years
- Resides in the United States
- Able to read and understand English and willing to provide informed consent and comply with the study protocol
- Moderate depressive symptom severity, as indicated by the Patient Health Questionnaire-9 (PHQ-9)
- Problematic cannabis use, as indicated by the Cannabis Use Disorder Identification Test - Revised (CUDIT-R)
- Current elevated anhedonia, as indicated by the PHQ-9
- Interest in receiving treatment for their cannabis use and depression
- Meet criteria for current Major Depressive Disorder and Cannabis Use Disorder per the DSM-5
You will not qualify if you...
- History of a psychotic disorder or bipolar disorder type I or II
- Active suicidal ideation or intent based on the Columbia-Suicide Severity Rating Scale
- Current psychotherapy engagement
- Changes in psychotropic medication within six weeks before starting the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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