Comparing Oral Atenolol and Metoprolol for Controlled Hypotensive Anesthesia in Nasal Surgery A Randomized Phase 4 Clinical Trial

What this Trial Is About

Researchers are comparing the safety and effectiveness of two oral medications, atenolol and metoprolol, used as premedications for controlled hypotensive anesthesia in patients undergoing nasal surgeries. This phase four, prospective, randomized, double-blind clinical trial addresses the issue of mucosal bleeding, a common complication that can increase surgery time and blood loss during nasal operations. Participants are divided into two groups one receives oral atenolol 50 mg and the other oral metoprolol 100 mg as premedication. The study involves controlled hypotensive anesthesia during the nasal surgery procedure. The trial is conducted under rigorous conditions including quadruple masking and random allocation to ensure unbiased comparison. During the study, participants blood loss is measured five minutes after surgery to evaluate the primary outcome. The trial includes assessments of safety and efficacy throughout the procedure. The total participation period spans from premedication administration through surgery and immediate postoperative monitoring. The trial is sponsored by Damanhour Teaching Hospital and runs until January 2026.

Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries