Actively Recruiting
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries
Led by Damanhour Teaching Hospital · Updated on 2025-08-21
60
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries. Background: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding. Patients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.
CONDITIONS
Official Title
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiologists (ASA) physical status 64 II
- Age from 21 to 50 years
You will not qualify if you...
- ASA physical status > II
- Age < 21 years or > 50 years
- Pregnant women
- Breastfeeding
- Bronchial asthma
- Chronic obstructive pulmonary disease
- Diabetes Mellitus
- Hypertension
- Ischemic heart disease
- Rheumatic heart disease
- Heart failure
- Heart block
- Sick sinus syndrome
- Sinus bradycardia
- Chronic hypotension
- Anemia (Hb < 10 g/dl)
- Renal or hepatic dysfunction
- Central nervous system disease
- Allergic fungal sinusitis
- Patients on beta-blockers
- Alcohol or drug abuse
- Anticoagulation therapy
- Bleeding diathesis
- Agents influencing autonomic nervous system
- Allergy to the study drugs
- Any contraindication of oral intake
AI-Screening
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Trial Site Locations
Total: 1 location
1
Damanhour Teaching Hospital
Damanhūr, El-Beheira, Egypt
Actively Recruiting
Research Team
A
Ahmed M Shaat, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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