Actively Recruiting
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries A Randomized Clinical Trial
Led by Damanhour Teaching Hospital · Updated on 2025-08-21
60
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing the safety and effectiveness of two oral medications, atenolol and metoprolol, used as premedications for controlled hypotensive anesthesia in patients undergoing nasal surgeries. This phase four, prospective, randomized, double-blind clinical trial addresses the issue of mucosal bleeding, a common complication that can increase surgery time and blood loss during nasal operations. Participants are divided into two groups: one receives oral atenolol 50 mg and the other oral metoprolol 100 mg as premedication. The study involves controlled hypotensive anesthesia during the nasal surgery procedure. The trial is conducted under rigorous conditions including quadruple masking and random allocation to ensure unbiased comparison. During the study, participants' blood loss is measured five minutes after surgery to evaluate the primary outcome. The trial includes assessments of safety and efficacy throughout the procedure. The total participation period spans from premedication administration through surgery and immediate postoperative monitoring. The trial is sponsored by Damanhour Teaching Hospital and runs until January 2026.
CONDITIONS
Brief Title
Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- American Society of Anesthesiologists (ASA) physical status 64 II
- Age from 21 to 50 years
You will not qualify if you...
- ASA physical status > II
- Age < 21 years or > 50 years
- Pregnant women
- Breastfeeding
- Bronchial asthma
- Chronic obstructive pulmonary disease
- Diabetes Mellitus
- Hypertension
- Ischemic heart disease
- Rheumatic heart disease
- Heart failure
- Heart block
- Sick sinus syndrome
- Sinus bradycardia
- Chronic hypotension
- Anemia (Hb < 10 g/dl)
- Renal or hepatic dysfunction
- Central nervous system disease
- Allergic fungal sinusitis
- Patients on beta-blockers
- Alcohol or drug abuse
- Anticoagulation therapy,
- Bleeding diathesis
- Agents influencing autonomic nervous system
- Allergy to the study drugs
- Any contraindication of oral intake
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to the day of surgery
Participants receive premedication with either Atenolol or Metoprolol before undergoing controlled hypotensive anesthesia during nasal surgery.
1 premedication and surgery visit
Duration - 5 minutes after the end of surgery
Participants are monitored after surgery to assess blood loss and recovery.
1 post-operative visit
Trial Site Locations
Total: 1 location
1
Damanhour Teaching Hospital
Damanhūr, El-Beheira, Egypt
Actively Recruiting
Research Team
A
Ahmed M Shaat, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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