Comparing Preoperative Medications to Manage Pain After Root Canal in Adults with Symptomatic Irreversible Pulpitis

What this Trial Is About

This research aims to compare the effects of preoperative use of alpha-chemo-trypsin, ibuprofen, and acetaminophen in controlling pain after root canal treatment in patients with symptomatic irreversible pulpitis. The study seeks to understand which premedication works best to manage post-endodontic pain. It is a randomized, triple-blinded clinical trial sponsored by Gulf Medical University and focuses on adults aged 20 to 50 years. Participants will receive one of the study medicationsalpha-chemo-trypsin, ibuprofen, acetaminophen, or a placeboone hour before undergoing root canal treatment. The procedure includes local anesthesia, access cavity preparation, cleaning and shaping of the root canal, obturation, and final restoration following a standardized protocol. During the study, patients will report their pain levels using a visual analogue scale at 6, 12, 24, and 48 hours after the treatment. Researchers will record preoperative pain scores and monitor post-endodontic pain intensity at these intervals to evaluate the effectiveness of each premedication. The total study duration for each participant corresponds to the follow-up pain assessments within two days after treatment.

Premedication on Post-endodontic Pain