Actively Recruiting
Preoperative Acetazolamide for Improved Pain Control Following Laparoscopic Hysterectomy
Led by Prisma Health-Upstate · Updated on 2026-02-20
100
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether giving patients acetazolamide, a medicine also called Diamox, before laparoscopic hysterectomy surgery can reduce pain after the operation. The study focuses on pain caused by the gas used to inflate the abdomen during this minimally invasive surgery. Researchers will compare acetazolamide to a placebo to see if it helps lessen the pain experienced in the abdomen, pelvis, and right shoulder area, which may be irritated by the gas. Participants will receive either a 500mg extended-release oral capsule of acetazolamide or an inactive placebo capsule before surgery. The study uses a randomized, double-blind design, meaning neither the patient nor the doctor knows which treatment is given. The main treatment period covers the time before surgery and up to 24 hours after, during which pain levels and pain medication use will be closely monitored. During the study, patients will rate their abdominal, pelvic, and right shoulder pain at five specific times from before surgery to 24 hours afterward using a visual scale. Researchers will also track how much pain medicine patients use after surgery. This will help determine if acetazolamide improves pain control. The trial will follow patients throughout this period and collect detailed pain and medication data to assess outcomes.
CONDITIONS
Brief Title
Preoperative Acetazolamide
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women
- Ages 21 to 65 years
- Undergoing total laparoscopic hysterectomy for benign indications with or without bilateral salpingoophorectomy
- Undergoing total laparoscopic hysterectomy for benign indications with or without cystoscopy
You will not qualify if you...
- Allergy to acetazolamide or sulfonamides
- Known electrolyte disturbances
- Pregnancy
- Kidney failure or creatinine greater than 1.5
- Diuretic or lithium use
- Chronic obstructive pulmonary disease (COPD) or other lung disease
- Central nervous system disorders
- Liver disease
- Glaucoma
- Preoperative or chronic opioid use
- Diagnosis of fibromyalgia
- Preoperative shoulder pain
- Conversion to laparotomy
- Intraoperative bladder or bowel injury
- Inability to understand or utilize visual analog scale
- Undergoing concurrent reconstructive procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From preoperative administration until 24 hours after surgery
Participants receive either acetazolamide or a placebo before their laparoscopic hysterectomy to help control postoperative pain.
1 preoperative visit and assessments up to 24 hours post procedure
Trial Site Locations
Total: 1 location
1
Prisma Health
Greenville, South Carolina, United States, 29605
Actively Recruiting
Research Team
P
Patti Parker, BSN
P
Paul Miller, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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