Actively Recruiting
Preoperative Acetazolamide
Led by Prisma Health-Upstate · Updated on 2026-02-20
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.
CONDITIONS
Official Title
Preoperative Acetazolamide
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants
- Ages 21 to 65 years
- Undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy
- Undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy
You will not qualify if you...
- Allergy to acetazolamide or sulfonamides
- Known electrolyte disturbances
- Pregnancy
- Kidney failure or creatinine greater than 1.5
- Use of diuretics or lithium
- Chronic obstructive pulmonary disease (COPD) or other lung diseases
- Central nervous system disorders
- Liver disease
- Glaucoma
- Preoperative or chronic opioid use
- Diagnosis of fibromyalgia
- Preoperative shoulder pain
- Conversion to laparotomy during surgery
- Intraoperative bladder or bowel injury
- Inability to understand or use the visual analog scale
- Undergoing concurrent reconstructive procedures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prisma Health
Greenville, South Carolina, United States, 29605
Actively Recruiting
Research Team
P
Patti Parker, BSN
CONTACT
P
Paul Miller, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here