Preoperative Acetazolamide to Reduce Pain After Laparoscopic Hysterectomy A Study Comparing Acetazolamide to Placebo for Post-Surgery Pain Control

What this Trial Is About

Researchers are evaluating whether giving patients acetazolamide, a medicine also called Diamox, before laparoscopic hysterectomy surgery can reduce pain after the operation. The study focuses on pain caused by the gas used to inflate the abdomen during this minimally invasive surgery. Researchers will compare acetazolamide to a placebo to see if it helps lessen the pain experienced in the abdomen, pelvis, and right shoulder area, which may be irritated by the gas. Participants will receive either a 500mg extended-release oral capsule of acetazolamide or an inactive placebo capsule before surgery. The study uses a randomized, double-blind design, meaning neither the patient nor the doctor knows which treatment is given. The main treatment period covers the time before surgery and up to 24 hours after, during which pain levels and pain medication use will be closely monitored. During the study, patients will rate their abdominal, pelvic, and right shoulder pain at five specific times from before surgery to 24 hours afterward using a visual scale. Researchers will also track how much pain medicine patients use after surgery. This will help determine if acetazolamide improves pain control. The trial will follow patients throughout this period and collect detailed pain and medication data to assess outcomes.

Preoperative Acetazolamide