Study Comparing Preoperative Clindamycin Vaginal Cream and Povidone-Iodine Cleansing to Prevent Infections After Cesarean Section

What this Trial Is About

This trial evaluates the effects of preoperative use of clindamycin vaginal cream compared to vaginal cleansing with a 10% povidone-iodine solution on infections after cesarean section. It focuses on postpartum infectious complications, particularly surgical site infections, in women undergoing elective cesarean sections. The study is a randomized, single-blind phase 4 trial sponsored by Beni-Suef University, aiming to improve infection control methods for this group. Participants are randomly assigned to one of three groups a control group receiving standard prophylactic antibiotics only, a group using clindamycin vaginal cream applied nightly for three nights before surgery, or a group receiving vaginal cleansing with povidone-iodine solution just before skin incision. All participants receive standard spinal anesthesia, catheterization, antiseptic skin preparation, and postoperative antibiotics according to hospital protocols. Education on wound care and infection symptoms is provided to all. During the study, participants are monitored for signs of infection up to three weeks after surgery. Evaluations include clinical assessments of the surgical site and symptoms such as fever, discharge, pain, swelling, redness, or wound opening. The primary outcome is the occurrence of wound infection within three weeks. Participants receive routine postoperative care and are advised to seek hospital care if infection symptoms appear. The total participation period includes the preoperative treatment and the three-week follow-up.

Preoperative Clindamycin Vaginal Cream Versus Vaginal Cleansing With Povidone-iodine on Postoperative Infections After Cesarean Section