Actively Recruiting
Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter
Led by Jan Calissendorff · Updated on 2026-02-10
182
Participants Needed
1
Research Sites
367 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy
CONDITIONS
Official Title
Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hyperthyroidism accepted for thyroidectomy due to toxic nodular goiter with free T4 <30 pmol/L or Graves' disease
- Signed informed consent
You will not qualify if you...
- Unstable coronary artery disease
- Previous thyroid surgery
- Congestive heart failure
- Renal insufficiency
- Hepatic failure
- Current infection
- Treatment with steroids or anticoagulants
- Thyroid associated orbitopathy CAS > 2
- Diabetes mellitus type 1
- Active cancer
- Severe psychiatric illness
- Amiodarone treatment
- Pregnancy
- Breast feeding
- Women of child bearing potential not using contraceptive
- Inability to comprehend the meaning of the study
- Iodine hypersensitivity
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Endocrinology, Karolinska University Hospital
Solna, Stockholm County, Sweden, 17176
Actively Recruiting
Research Team
J
Jan Calissendorff, MD, PhD
CONTACT
F
Fredric Hedberg, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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