Actively Recruiting

Phase Not Applicable
Age: 18Years - 75Years
All Genders
Healthy Volunteers
ID05520593

Preoperative Oral Hydration in the Ambulatory Arthroplasty Population: A Single-Blinded Randomized Controlled Trial

Led by Hospital for Special Surgery, New York · Updated on 2026-04-13

312

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating whether drinking a complex carbohydrate drink before surgery can reduce hospital stay length and improve same-day discharge rates for patients undergoing ambulatory total joint arthroplasty, including knee and hip replacements. This study aims to address issues like postoperative nausea, vomiting, and dizziness by optimizing preoperative hydration, which may influence recovery and discharge outcomes. The trial is a single-blinded randomized controlled study sponsored by the Hospital for Special Surgery. Participants are divided into two groups: one drinks a 400ml complex carbohydrate drink containing 50g of carbohydrates three hours before surgery in the preoperative holding area, while the other group follows standard preoperative fluid guidelines without the carbohydrate drink. Both groups must fast from solid foods after midnight on the day of surgery and may only consume clear liquids up to three hours before surgery. The study focuses on same-day discharge for ambulatory total knee and hip arthroplasty, including certain revision surgeries. During the study, participants will be monitored from admission through discharge for up to one week, tracking length of hospital stay, physical therapy sessions, walking distance, stair climbing, and episodes of orthostatic hypotension. Patient-reported outcome scores and urine tests are collected before surgery and up to four months post-operation. Costs related to the hospital stay will also be assessed. The study includes safety monitoring and aims to improve perioperative management in this surgical population.

CONDITIONS

Brief Title

Preoperative Oral Hydration in the Ambulatory Arthroplasty Population

Who Can Participate

Age: 18Years - 75Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Candidates for ambulatory total knee arthroplasty
  • Candidates for ambulatory total hip arthroplasty
  • Candidates for ambulatory revision knee arthroplasty (liner exchange only)
  • Candidates for ambulatory revision hip arthroplasty (liner exchange only)
  • Case scheduled before noon (12 pm)
  • Patient agrees to same-day discharge and has a responsible adult to spend the night on the day of discharge
  • Age between 18 and 75 years
Not Eligible

You will not qualify if you...

  • Body mass index (BMI) less than 18.5 or greater than 37.0
  • Diabetes
  • Chronic kidney disease
  • Clotting disorders
  • Neurological conditions preventing control of the affected limb
  • Pregnant women
  • Patients scheduled as ambulatory due to insurance mandates
  • History of active ischemia
  • Significant valvular heart disease
  • Significant arrhythmias
  • Obstructive sleep apnea per Hospital for Special Surgery guidelines
  • Chronic opioid dependence (daily use for six or more months)
  • Glomerular filtration rate less than 60 ml/min

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Day of surgery

Participants receive a complex carbohydrate drink 3 hours before surgery or follow standard preoperative fluid guidelines. Participants fast from solid foods after midnight the morning of surgery and may drink clear fluids up to 3 hours prior to surgery.

1 visit (preoperative holding area)

Post-operative Follow-up

Duration - Up to 4 months

Participants are monitored from admission to discharge, including physical therapy sessions and mobility assessments, with outcomes measured up to 1 week post-surgery. Additional follow-up includes assessment of recovery scores up to 4 months after surgery.

Multiple visits including inpatient stay and at least 1 post-operative visit

Trial Site Locations

Total: 1 location

1

Hospital for Special Surgery

New York, New York, United States, 10021

Actively Recruiting

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Research Team

J

Jose Rodriguez, MD

R

Ricardo Torres-Ramirez, BS

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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