Actively Recruiting
Preoperative Preradiotherapy TTFields
Led by The Christie NHS Foundation Trust · Updated on 2026-05-08
42
Participants Needed
1
Research Sites
105 weeks
Total Duration
On this page
Sponsors
T
The Christie NHS Foundation Trust
Lead Sponsor
U
University of Manchester
Collaborating Sponsor
AI-Summary
What this Trial Is About
PreOperative PreRAdIotherapy Tumour Treating Fields (PORTRAIT) is a Phase I study that will test the safety and feasibility of Optune administered preoperatively and preradiotherapy in patients with a new radiological diagnosis of glioblastoma (GBM). Participants will be required to undergo additional MRI sequencing scans and provide blood, tear fluid and tissue samples over a maximum of 6 months. After the study patients will follow their standard treatment pathway.
CONDITIONS
Official Title
Preoperative Preradiotherapy TTFields
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is aged >35 years
- Patient is male or female
- Patient has a new radiological diagnosis of glioblastoma
- Patient has a performance status judged by WHO, ECOG score 0-1
- Patient has been reviewed by Neuro-oncology MDT with consensus that study entry is clinically appropriate and safe
- Principal Investigator has confirmed study entry is clinically appropriate and safe
- Intention to treat with surgical resection and postoperative adjuvant therapy as per standard of care
- Adequate hematological and biochemical parameters for surgery and contrast agent administration
- Patient has mental capacity to consent
- Patient is able and willing to give informed consent
- Patient is able and willing to comply with continuous head shaving
- Patient is able and willing to wear Optune equipment for the required duration
You will not qualify if you...
- Patients with uncontrolled seizures
- Patients planned for biopsy procedure only
- Patients suspected of other tumors or known malignancy except non-melanoma skin cancer or certain prostate cancers within past 3 years
- Patients with contraindications to contrast-enhanced MRI (e.g., claustrophobia, gadolinium allergy)
AI-Screening
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Trial Site Locations
Total: 1 location
1
The Christie NHS Foundation Trust
Manchester, United Kingdom, M204BX
Actively Recruiting
Research Team
G
Gerben R Borst, MD PhD
CONTACT
M
Melanie Oddy
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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