Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT07411625

Preoperative Rehabilitation for Patient With an ACL Injury

Led by Nantes University Hospital · Updated on 2026-03-20

84

Participants Needed

1

Research Sites

73 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Muscle qualities are critical for the recovery after an anterior cruciate ligament (ACL) injury. Before ACL reconstruction (ALCR), resistance training aims to maintain patient strength and volume in order to optimize recovery. Unanswered questions remain on the modalities of resistance training before ACLR. This protocol details a pragmatic clinical trial that primary aims to increase the maximal strength of knee extensors and flexors and to induce hypertrophy before ACLR. Participants awaiting ACLR will be recruited from outpatient rehabilitation clinics and will be randomly allocated to one group to attend a 9-weeks rehabilitation program before ACLR. Participants of 'resistance training' group will perform a training program built on the principles of strength training to increase knee muscles strength and volume. Three blocks of 3 weeks will induce a progressive increase in training load, with exercises performed close to failure. Participants of 'usual group' will perform traditional exercises including: balance/proprioceptive exercises, weight-balances exercises, and body-weight resistance training exercises. Groups will be compared on muscle strength (primary outcome), clinical outcomes (muscle volume, stiffness, knee mobility, effusion) and self-reported outcomes (quality of life, perception of knee function, pain, anxiety and depression, exertion, health consumption, participations in activities) before and after ACLR. Outcomes will be collected by a blinded assessor before and after the resistance training program (before ACLR); 4 and 9 months after the ACLR.

CONDITIONS

Official Title

Preoperative Rehabilitation for Patient With an ACL Injury

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Being over 18 years
  • A first episode of an ACL injury
  • An ACL reconstruction scheduled at least 10 weeks later using hamstring, gracilis, or quadriceps/patellar tendon autograft
  • Knee passive range of motion between 10° extension deficit and 80° flexion
  • A medical prescription for prehabilitation
  • Ability to attend prehabilitation and post-ACLR rehabilitation at one of the 15 clinics
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

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Trial Site Locations

Total: 1 location

1

University Hospital - Laboratoire "Motricité, Interactions, Performance" (UR 4334)

Nantes, France, 44000

Actively Recruiting

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Research Team

A

Antoine FROUIN

CONTACT

G

Guillaume LE SANT

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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