Actively Recruiting
Preoperative Rehabilitation for Patient With an ACL Injury
Led by Nantes University Hospital · Updated on 2026-03-20
84
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Muscle qualities are critical for the recovery after an anterior cruciate ligament (ACL) injury. Before ACL reconstruction (ALCR), resistance training aims to maintain patient strength and volume in order to optimize recovery. Unanswered questions remain on the modalities of resistance training before ACLR. This protocol details a pragmatic clinical trial that primary aims to increase the maximal strength of knee extensors and flexors and to induce hypertrophy before ACLR. Participants awaiting ACLR will be recruited from outpatient rehabilitation clinics and will be randomly allocated to one group to attend a 9-weeks rehabilitation program before ACLR. Participants of 'resistance training' group will perform a training program built on the principles of strength training to increase knee muscles strength and volume. Three blocks of 3 weeks will induce a progressive increase in training load, with exercises performed close to failure. Participants of 'usual group' will perform traditional exercises including: balance/proprioceptive exercises, weight-balances exercises, and body-weight resistance training exercises. Groups will be compared on muscle strength (primary outcome), clinical outcomes (muscle volume, stiffness, knee mobility, effusion) and self-reported outcomes (quality of life, perception of knee function, pain, anxiety and depression, exertion, health consumption, participations in activities) before and after ACLR. Outcomes will be collected by a blinded assessor before and after the resistance training program (before ACLR); 4 and 9 months after the ACLR.
CONDITIONS
Official Title
Preoperative Rehabilitation for Patient With an ACL Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Being over 18 years
- A first episode of an ACL injury
- An ACL reconstruction scheduled at least 10 weeks later using hamstring, gracilis, or quadriceps/patellar tendon autograft
- Knee passive range of motion between 10° extension deficit and 80° flexion
- A medical prescription for prehabilitation
- Ability to attend prehabilitation and post-ACLR rehabilitation at one of the 15 clinics
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Hospital - Laboratoire "Motricité, Interactions, Performance" (UR 4334)
Nantes, France, 44000
Actively Recruiting
Research Team
A
Antoine FROUIN
CONTACT
G
Guillaume LE SANT
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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