Actively Recruiting
Preoperative Stereotactic Radiotherapy for Treatment of Spinal Metastases
Led by University Medical Center Goettingen · Updated on 2025-08-22
20
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this interventional clinical trial is to evaluate the efficacy and safety of preoperative hypofractionated Stereotactic Body Radiotherapy (SBRT) in the treatment of patients undergoing surgery for spinal metastases. The main questions this study aims to answer are: * Does preoperative SBRT result in local tumor control at the involved spinal segments as assessed by MRI/CT scan at 3 and 6 months postoperatively? * What are the postoperative outcomes in terms of pain intensity, functional status and quality of life? Participants will receive hypofractionated SBRT to spinal metastases shortly before surgical intervention. Participants will undergo preoperative and follow-up assessments, including: * MRI and CT scans before and after surgery and at 3 and 6 months after surgery to measure tumor size * Pain questionnaires where patients rate their current pain, worst pain, and average pain in the last 24 hours on a scale from 0 (no pain) to 10 (worst pain imaginable) * A short questionnaire (Karnofsky Performance Status) to assess the patient's general ability to carry out daily activities * Several patient questionnaires to evaluate back pain, physical limitations, and overall quality of life (Oswestry Disability Index, EORTC QLQ-C30, and EORTC QLQ-BM22)
CONDITIONS
Official Title
Preoperative Stereotactic Radiotherapy for Treatment of Spinal Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Indication for surgical treatment of a spinal tumor
- Age 18 years or older
- Estimated survival longer than 6 months
- Ability to understand the study information and make a decision to participate
You will not qualify if you...
- Age under 18 years
- Motor deficit or loss of bladder and bowel control requiring emergency surgical decompression
- Tumor extent not suitable for hypofractionated SBRT (1-3 fractions)
AI-Screening
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Trial Site Locations
Total: 1 location
1
University Medical Center Goettingen
Göttingen, Germany, 37073
Actively Recruiting
Research Team
C
Carla Marie Zwerenz, Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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