Actively Recruiting
Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)
Led by Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Updated on 2025-12-11
50
Participants Needed
1
Research Sites
312 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate the feasibility and peri-operative complications of preoperative hypo-fractionated radiotherapy followed by surgery for retroperitoneal sarcoma
CONDITIONS
Official Title
Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma (FUSION-01)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary soft tissue sarcoma of retroperitoneal or infra-peritoneal spaces of pelvis
- Sarcoma not originated from bone structure, abdominal or gynecological viscera
- All disease can be included safely within one radiotherapy field
- Absence of extension through the sciatic notch or across the diaphragm
- Histologically proven sarcoma excluding gastrointestinal stromal tumors, rhabdomyosarcoma, PNET or other small round blue cell sarcomas, osteosarcoma, chondrosarcoma, aggressive fibromatosis, sarcomatoid or metastatic carcinoma
- ECOG performance status 0 to 2
- American Society of Anesthesiologist score 2 or less
- Normal renal function with calculated Creatinine Clearance of 50 ml/min or higher and functional contralateral kidney
- Normal bone marrow and hepatic function
- Contraception needed for females of child-bearing age or males with partners of child-bearing age
- Expected life expectancy longer than 5 years
- Written consent form given prior to treatment
- Can safely be treated by radiotherapy and surgery
You will not qualify if you...
- Metastatic disease
- Tumor previously treated by radiotherapy
- Involvement of liver, pancreatic head or duodenum
AI-Screening
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Trial Site Locations
Total: 1 location
1
Radiotherapy Department of Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100021
Actively Recruiting
Research Team
N
Ning-Ning Lu
CONTACT
S
Shu-Lian Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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