Actively Recruiting
Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
Led by United States Naval Medical Center, Portsmouth · Updated on 2025-05-21
132
Participants Needed
1
Research Sites
222 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.
CONDITIONS
Official Title
Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 79 years
- Undergoing elective gynecological surgery by open abdominal, endoscopic, or vaginal approach
- Surgery performed under general anesthesia
You will not qualify if you...
- Pregnant women
- Patients with gastrointestinal disease needing ongoing medical treatment
- History of gastrointestinal surgery except diagnostic procedures, appendectomy, or cholecystectomy
- Use of H2 receptor blockers, proton pump inhibitors, or GERD therapy within 30 days before surgery
- History of postoperative nausea and vomiting requiring extra prevention measures
- Known or suspected malignancy
- Lactose intolerance
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Naval Medical Center Portsmouth
Portsmouth, Virginia, United States, 23708
Actively Recruiting
Research Team
C
Casey Timmerman, DO
CONTACT
M
Melissa Infosino, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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