Actively Recruiting
Preoptimisation in Ventral Hernia Surgery
Led by Umeå University · Updated on 2026-01-05
130
Participants Needed
5
Research Sites
205 weeks
Total Duration
On this page
Sponsors
U
Umeå University
Lead Sponsor
R
Region Norrbotten
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study is a multicentre, single-blinded, randomised controlled trial. Ventral hernia patients with an aperture width between four and eight centimetres are randomised to either participation in a multimodal preoptimisation programme, including interventions to increase physical activity, promote weight loss, and optimise the treatment of comorbidities, or to surgery without structured preoptimisation. The primary endpoint is complications at three months postoperatively. During surgery, biopsies of skin, muscle, and fascia will be collected, along with pre- and postoperative blood samples, to analyse the molecular effects of preoptimisation, particularly in relation to collagen metabolism.
CONDITIONS
Official Title
Preoptimisation in Ventral Hernia Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a ventral hernia with a defect width of at least 4 cm.
- Symptom burden related to the hernia sufficient to justify surgical intervention.
- Age 65 18 years.
You will not qualify if you...
- Expected survival of less than three years.
- Inability to comprehend oral and written information or to provide informed consent.
- Acute complication of the hernia requiring emergency surgical intervention.
- General condition characterised by severe limitations in physical functional capacity.
AI-Screening
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Trial Site Locations
Total: 5 locations
1
Gällivare hospital
Gällivare, Norrbotten County, Sweden, 98238
Actively Recruiting
2
Sunderby Hospital
Luleå, Norrbotten County, Sweden, 94542
Actively Recruiting
3
Lycksele Hospital
Lycksele, Västerbotten County, Sweden, 92137
Not Yet Recruiting
4
Skellefteå Hospital
Skellefteå, Västerbotten County, Sweden, 93141
Not Yet Recruiting
5
Umeå University Hospital
Umeå, Västerbotten County, Sweden
Actively Recruiting
Research Team
G
Gunnar Nordqvist, M.D.
CONTACT
V
Viktor Holmdahl, Phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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