Actively Recruiting
PrEP Readiness Interventions for Sustained Motivation (PRISM)
Led by Florida International University · Updated on 2026-05-07
400
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a hybrid type I randomized controlled trial to test the effectiveness of contingency management (CM) alone versus CM with motivational interviewing (MI) for optimizing entry or re-entry into the HIV prevention or care continua. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via telehealth. Monthly follow-up assessments will be completed over 12 months to examine effectiveness MI+CM for the primary outcome - filling a pre-exposure prophylaxis (PrEP) or anti-retroviral therapy (ART) prescription (verified using a digital photo). Secondary outcomes will include: self-reported PrEP or ART clinical evaluation by a provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).
CONDITIONS
Official Title
PrEP Readiness Interventions for Sustained Motivation (PRISM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- Assigned male at birth
- Self-reported methamphetamine use in the past 3 months
- HIV-negative or unknown serostatus at baseline
- Has not filled a PrEP prescription in the past 6 months
You will not qualify if you...
- Unwilling or unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Florida International University
Miami, Florida, United States, 33199
Actively Recruiting
Research Team
A
Adam Carrico Professor, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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