What is conscientiousness coaching studying for people with Multiple Sclerosis?

This study is evaluating whether coaching focused on goal-directed behavior can enhance the effects of cognitive rehabilitation for people with Multiple Sclerosis. Researchers aim to improve cognitive functions like memory and processing speed by personalizing training through apps and coaching. The study is sponsored by Universiteit Leiden and involves multiple countries.

Who may be eligible for this Multiple Sclerosis clinical trial?

Adults aged 18 to 65 years with confirmed relapsing remitting or secondary progressive MS may be eligible. Participants should have stable disease treatment and no recent relapses. Both men and women can join. Please review eligibility criteria for more details.

Is there any cost to participate in this Multiple Sclerosis clinical trial?

Study-related care, including the cognitive training apps and all trial visits, is provided at no cost. However, participants may have personal travel expenses that are not always covered. Participants should plan accordingly for any travel costs.

Actively Recruiting

Phase Not Applicable

Age: 18Years - 65Years

All Genders

ID07225868

Improving Cognitive Rehabilitation in Adults With Multiple Sclerosis Using Personalized Coaching and App Training

Led by Universiteit Leiden · Updated on 2025-11-10

126

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating whether coaching in goal-directed behavior can improve the success of cognitive rehabilitation in people with Multiple Sclerosis MS, who often face cognitive difficulties such as memory problems, concentration issues, and slower processing speed. This study focuses on enhancing cognitive functioning and quality of life through personalized, app-based training programs that consider individual personality traits, particularly conscientiousness. The study is a controlled, longitudinal, multicenter trial conducted in the Netherlands, USA, and Switzerland, funded by the National MS Fund and led by Leiden University.

CONDITIONS

Brief Title

Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?

Who Can Participate

Age: 18Years - 65Years

All Genders

Eligibility Criteria

You may qualify if you...

Confirmed diagnosis of relapsing remitting or secondary progressive Multiple Sclerosis according to McDonald 2017 criteria
Expanded Disability Status Scale (EDSS) score less than 7
Relapse-free period of at least 3 months
Unchanged disease modifying therapy for at least 2 months at time of inclusion
Age between 18 and 65 years
Language proficiency in Dutch, English, or German depending on study center

You will not qualify if you...

High conscientiousness with a T score of 65 or higher on the BFI-2 subscale
Current or prior brain trauma or neurological conditions other than Multiple Sclerosis
Psychiatric disorders that heavily impact cognitive or daily functioning
Medication intake or substance abuse that affects cognitive functioning
For Dutch participants undergoing MRI: any contradictions to MRI scanning

Research Team

Charlotte C Rouzee, MSc

Marit FL Ruitenberg, PhD

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Improving Cognitive Rehabilitation in Adults With Multiple Sclerosis Using Personalized Coaching and App Training

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria