Actively Recruiting
PREVENT: Preparedness Through Respiratory Virus Epidemiology and Community Engagement
Led by University of California, San Diego · Updated on 2025-11-04
25000
Participants Needed
2
Research Sites
8 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
S
San Ysidro Health Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are establishing the CHARM network through three main institutions—Beth Israel Deaconess Medical Center, the University of California San Diego (UCSD), and the University of Washington—along with their partners. The network will operate mainly via the PREVENT project, which studies respiratory infections including COVID-19, flu, and RSV. The study involves community members interested in respiratory infection testing, ongoing symptom tracking, an immunology sub-study, and household transmission monitoring. The study includes several components: Component A0 (Community Testing) offers no-cost testing through an app and vending machines where participants can self-collect nasal swabs for respiratory infection detection. Component A involves weekly symptom screening with nasal swabs and illness questionnaires at symptom onset and follow-ups on Days 7 and 14. The Immunology sub-study collects blood and saliva/nasal samples twice yearly and around infections or immunizations. Component B monitors household transmission with daily symptom questionnaires and nasal swabs for 14 days, plus blood or saliva samples at enrollment and 28 days later. Participants provide data and specimens over time, including PCR testing for respiratory viruses. Assessments include symptom tracking, questionnaire responses, and sample collections for immunologic analysis. The study measures respiratory illness rates, secondary infections, and gathers feedback through questionnaires and interviews over five years. Participants may be involved in different components depending on eligibility and interest, with ongoing monitoring and data collection throughout the study period.
CONDITIONS
Brief Title
Preparedness Through Respiratory Virus Epidemiology and Community Engagement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All community members can participate in the Community Testing Component.
- For Component A: All ages are eligible, must live in the service area of a recruitment center.
- Plans to remain living in the recruitment area for at least 2 years.
- For Component B index cases: Detection of a priority respiratory pathogen within 5 days and living in the recruitment area.
- Index case must live in a household with at least one other person and plan to stay for at least 14 days.
- Household contacts must routinely live in the same household as the index case and plan to stay for 14 days.
- Household must have at least one non-ill member on the day of screening or prior 5 days.
You will not qualify if you...
- No exclusion for the Community Testing Component; pregnancy and age do not exclude participation.
- For Component A: Inability to communicate in available languages, incarceration, living in congregate settings like nursing homes or dormitories with shared facilities.
- Unable or unwilling to participate in data and specimen collections.
- Unable to comply with study procedures as determined by investigators.
- Participation in other respiratory infection clinical trials within 3 months prior or during this study.
- For Component B index case: Lives in congregate settings or meets Component A exclusions.
- Household contacts hospitalized since primary case symptom onset or meeting Component A exclusions.
- Enrollment visit more than 6 days after first symptom onset.
- Primary case not enrolled or hospitalized after symptom onset.
AI-Screening
AI-Powered Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or virtual) for screening and registration
Duration - Ongoing throughout study participation
Participants access no cost testing for respiratory infections by self-collecting nasal swabs using the PREVENT App and vending machines when they feel sick or believe they have been exposed.
Participants collect and return test kits as needed using vending machines or drop-off locations
Duration - Weekly symptom screening throughout study duration
Participants complete weekly symptom surveys and provide nasal swabs and illness questionnaires on days 0, 7, and 14 if symptoms are reported.
Weekly surveys and up to 3 nasal swab collections per illness episode
Duration - Twice yearly and around infection or immunization events during study
A subset of participants provide blood and saliva/nasal fluid samples twice a year and before and after infection or immunization to study immune responses.
Approximately 2 to 4 specimen collection visits per year
Duration - 14 days following enrollment
Household members collect daily symptom questionnaires and nasal swabs for 14 days, with additional mucosal specimen collection and surveys.
Daily self-collection and questionnaires for 14 days
Trial Site Locations
Total: 2 locations
1
UC San Diego
La Jolla, California, United States, 92093
Actively Recruiting
2
San Ysidro Health
San Ysidro, California, United States, 92173
Actively Recruiting
Research Team
B
Breanna Reyes, MPH
P
PREVENT Project
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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