Actively Recruiting
Preparedness Through Respiratory Virus Epidemiology and Community Engagement
Led by University of California, San Diego · Updated on 2025-11-04
25000
Participants Needed
2
Research Sites
264 weeks
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
S
San Ysidro Health Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The CHARM network will be established through three primary institutions-Beth Israel Deaconess Medical Center (BIDMC), the University of California San Diego (UCSD), and the University of Washington (UW)-along with their subcontracting institutions. At UCSD and partner sites, the CHARM network will be implemented via the PREVENT project. All PREVENT participants will be consented in to Component A0 (Community Testing) and a subset of A0 participants will be invited to participate and will be consented into the other components: Component A (Ongoing Testing); Component A Sub-study (Immunology); Component B (Household Transmission). Component A0 participants (Community testing) will be members of the community who are interested in accessing testing for respiratory infections and will be asked to provide limited information that will then be used for screening for study Components A and/or B. Participants in Component A (Ongoing Testing ) will undergo weekly symptom screening. If they report symptoms, they will be asked to provide a nasal swab and complete illness questionnaires on the day they report symptoms (Day 0) and again on Days 7 and 14. Participants in Component A Sub-study (Immunology) will provide blood and saliva/nasal fluid samples twice a year, as well as before and after infection and/or immunization against priority pathogens. Participants in Component B (Household Transmission) will complete daily symptom questionnaires and nasal swabs for 14 days following enrollment, regardless of symptoms. Those who are symptomatic at enrollment will also complete retrospective daily diaries from symptom onset to the enrollment date. Additionally, they provide blood and/or saliva/nasal fluid samples at enrollment and again 28 days later. For all Components, UCSD will provide PCR test results for SARS-CoV-2, Influenza A/B, and RSV for nasal swab samples.
CONDITIONS
Official Title
Preparedness Through Respiratory Virus Epidemiology and Community Engagement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- All community members can participate in the community testing component.
- For Component A: Participants of all ages who live in the recruitment center's service area and plan to stay there for at least 2 years.
- For Component B index cases: Detection of a priority respiratory pathogen within 5 days, living in the service area, living with at least one other person in the household, planning to stay in the household for 14 days, and not hospitalized since symptom onset.
- For Component B household contacts: Routinely sleep in the same household as the index case, slept at least one night there in the 7 days before symptom onset, and plan to stay in the household for 14 days.
- For Component B household: At least one non-ill household member on eligibility day or previous 5 days, and all symptomatic persons had symptom onset within 5 days.
You will not qualify if you...
- For Component A: Unable to communicate in study languages, incarcerated, living in congregate settings (assisted living, nursing home, dormitories with shared facilities), unable or unwilling to participate in data/specimen collection, unable to comply with procedures, or participating in other respiratory virus clinical trials within 3 months prior or during study.
- For Component B index cases: Living in congregate settings or meeting Component A exclusion criteria.
- For Component B household contacts: Hospitalized since primary case symptom onset or meeting Component A exclusion criteria.
- For Component B household: Enrollment visit more than 6 days after primary case symptom onset, primary case not enrolled, or primary case hospitalized after symptom onset.
AI-Screening
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Trial Site Locations
Total: 2 locations
1
UC San Diego
La Jolla, California, United States, 92093
Actively Recruiting
2
San Ysidro Health
San Ysidro, California, United States, 92173
Actively Recruiting
Research Team
B
Breanna Reyes, MPH
CONTACT
P
PREVENT Project
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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