PREVENT Study Community and Household Testing and Immune Response Monitoring for Respiratory Viruses

What this Trial Is About

Researchers are establishing the CHARM network through three main institutionsBeth Israel Deaconess Medical Center, the University of California San Diego UCSD, and the University of Washingtonalong with their partners. The network will operate mainly via the PREVENT project, which studies respiratory infections including COVID-19, flu, and RSV. The study involves community members interested in respiratory infection testing, ongoing symptom tracking, an immunology sub-study, and household transmission monitoring. The study includes several components Component A0 Community Testing offers no-cost testing through an app and vending machines where participants can self-collect nasal swabs for respiratory infection detection. Component A involves weekly symptom screening with nasal swabs and illness questionnaires at symptom onset and follow-ups on Days 7 and 14. The Immunology sub-study collects blood and salivanasal samples twice yearly and around infections or immunizations. Component B monitors household transmission with daily symptom questionnaires and nasal swabs for 14 days, plus blood or saliva samples at enrollment and 28 days later. Participants provide data and specimens over time, including PCR testing for respiratory viruses. Assessments include symptom tracking, questionnaire responses, and sample collections for immunologic analysis. The study measures respiratory illness rates, secondary infections, and gathers feedback through questionnaires and interviews over five years. Participants may be involved in different components depending on eligibility and interest, with ongoing monitoring and data collection throughout the study period.

Preparedness Through Respiratory Virus Epidemiology and Community Engagement