Actively Recruiting
Presence of Anti-RACH Antibodies and Neurocognitive Disorder in Myasthenic or Alzheimers's Patients.
Led by Centre Hospitalier Universitaire de Nice · Updated on 2025-04-02
30
Participants Needed
1
Research Sites
110 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate if there is a specific association between the presence of anti Rach antibodies in the CSF and the presence of a cogntive disorder in myasthenic patients. Moreover the investigator wants to study if there is a link between the presence of Anti RACH antibodies in myasthenia and Alzheimers's disease. For that, the investigator will recruit myasthenic patient with cognitive disorder that has undergo a diagnostic process including lombar punction for memory trouble in Nice memory center as well as Alzheimer's patient having go through the same process. The study will consist in one additionnal blood draw. Anti RACH antibodies will be analyzed in historical CSF stored in biocollection and serum collected for the study. LCS of healthy control will also be analyzed.
CONDITIONS
Official Title
Presence of Anti-RACH Antibodies and Neurocognitive Disorder in Myasthenic or Alzheimers's Patients.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult person
- Diagnosis of anti-AChR positive autoimmune myasthenia gravis, confirmed by clinical and biological data, classified from class I to IV by MGFA
- Mild or major neurocognitive disorder diagnosed by DSM-5 criteria with CSF biomarker analysis at CMRR and agreement to bio-collect residual CSF (for myasthenia patients)
- Mild or major neurocognitive disorder diagnosed by DSM-5 criteria with CSF biomarker analysis at CMRR and agreement to bio-collect residual CSF (for Alzheimer's patients)
- Neurocognitive disorder linked only to Alzheimer's disease by IWG-2 criteria with typical or atypical clinical form and CSF biomarkers (for Alzheimer's patients)
- Signed informed consent
- Affiliated or beneficiary of a social security system
- Absence of memory complaint (for healthy controls)
- Absence of neurocognitive disorder (for healthy controls)
- Consent to research analysis on stored CSF samples in biobank (for healthy controls)
You will not qualify if you...
- Insufficient command of French language to understand, read, and write for neuropsychological tests (for myasthenia patients)
- Need to use routine CSF tube for additional diagnostic tests in routine care (for myasthenia patients)
- Vulnerable people as defined in articles L1121-5 to -8 including pregnant or breastfeeding women, persons deprived of liberty, involuntarily hospitalized persons, persons admitted for non-research purposes, persons under legal protection, or unable to consent (for all patients)
AI-Screening
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Trial Site Locations
Total: 1 location
1
CHU de Nice
Nice, Alpes Maritimes, France, 06000
Actively Recruiting
Research Team
L
LEMAIRE JUSTINE
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
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