Actively Recruiting
Presepsin Diagnostic Performance in Severe Burn Sepsis
Led by Dohern Kym · Updated on 2025-08-11
138
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study enrolls approximately 270 adult patients with severe burns covering at least 20% of total body surface area to evaluate how well the blood biomarker presepsin diagnoses sepsis early in this high-risk population. Sepsis-a life-threatening condition caused by an exaggerated immune response to infection-is particularly urgent to detect promptly in burn patients. Participants will undergo blood tests for presepsin at predefined time points, and these results will be compared to C-reactive protein (CRP), procalcitonin (PCT) levels, Sepsis-3 clinical criteria, and blood culture findings. The primary goal is to measure presepsin's sensitivity and specificity for sepsis detection, thereby determining its diagnostic accuracy. Findings from this study may enable faster sepsis treatment in severe burn patients and improve clinical outcomes.
CONDITIONS
Official Title
Presepsin Diagnostic Performance in Severe Burn Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older admitted to Hangang Sacred Heart Hospital Burn ICU
- Burns covering 20% or more of total body surface area
- Clinical suspicion of sepsis prompting blood culture and biomarker sampling
- Ability to understand the study and provide written informed consent or have a legally authorized representative consent
You will not qualify if you...
- Unable to have research blood drawn due to emergency surgery or major trauma at sampling time
- Chronic immunosuppressive conditions such as long-term high-dose steroids, organ transplant, or congenital immunodeficiency
- Pregnant women or individuals with significant psychiatric conditions preventing consent
- Any other medical or safety concerns judged inappropriate by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Hangang Sacred Heart Hospital, Hallym University Medical Center
Seoul, Seoul, South Korea, 07981
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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