Actively Recruiting
Preserving Geriatric Muscle With an Osteoporosis Medication
Led by Susan L. Greenspan · Updated on 2026-02-10
155
Participants Needed
1
Research Sites
268 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our goal is to demonstrate efficacy of the novel agent Denosumab to improve or preserve muscle health, strength, mobility and function in frail older adults.
CONDITIONS
Official Title
Preserving Geriatric Muscle With an Osteoporosis Medication
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ambulatory male and female residents aged 65 and older with osteoporosis or low bone mass at risk for fracture
- Resident of an institution such as a nursing home, assisted living facility, or senior community
- Diagnosis of osteoporosis by spine, hip or forearm BMD T-score of -2.5 or less, or previous adult fragility spine or hip fracture
- Or osteopenia with treatment indication based on FRAX 10-year major fracture risk of 20% or higher or hip fracture risk of 3% or higher using femoral neck BMD
You will not qualify if you...
- Residents with subacute illnesses or life expectancy less than 1 year
- Currently on related osteoporosis therapy including bisphosphonates, Denosumab, teriparatide, abaloparatide, or romosozumab
- Bisphosphonate use for more than 1 year during the previous 2 years
- History of low blood calcium or contraindication to treatment
- Use of systemic glucocorticoids that may reduce muscle strength
- Vitamin D levels below 25 ng/mL unless treated to 25 ng/mL or higher
- Suggested to stop calcitonin due to cancer concerns
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Barnabas Woodlands
Pittsburgh, Pennsylvania, United States, 16059
Actively Recruiting
Research Team
S
Susan Greenspan, MD
CONTACT
N
Nicholas Gatto, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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