Actively Recruiting
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
Led by Unity Health Toronto · Updated on 2025-05-20
20
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator. This support aims at avoiding excessive inspiratory effort, while ensuring a certain degree of training of the patient's inspiratory muscle. Avoiding both minimal and excessive assistance is thus important for the optimal care of the intubated patient ensuring a lung and diaphragm protective ventilation with the goal to liberate the patient from the ventilator as soon as possible. Recently pressure-muscle-index (PMI), an index of inspiratory effort easy to be measured on the ventilator screen, has been proposed to avoid excessive assistance in PSV. This will be the first prospective study testing the effects of setting pressure support based on PMI to avoid excessive assistance on patients recovering from acute lung injury (acute hypoxemic respiratory failure).
CONDITIONS
Official Title
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Receiving invasive ventilation in an Intensive Care Unit
- Diagnosed with acute hypoxemic respiratory failure with a P/F ratio below 300 mmHg
- Currently breathing using pressure support ventilation
You will not qualify if you...
- Under 18 years of age
- Contraindications to Electrical Impedence Tomography monitoring such as pacemaker or burns/wounds that limit electrode placement
- Severe, previously diagnosed neurological or neuromuscular disease
- Psychomotor agitation with a Sedation Agitation Scale score over 4
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
Research Team
L
Laurent Brochard, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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