Actively Recruiting
Pressure-Volume Loop Assessment in Valvular Heart Disease
Led by Nantes University Hospital · Updated on 2025-09-16
70
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
N
Nantes University Hospital
Lead Sponsor
F
Fédération Française de Cardiologie
Collaborating Sponsor
AI-Summary
What this Trial Is About
The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD). Invasive RV-PA coupling is measured by using conductance catheters, the gold standard assessment for ventricular physiology. Several non-invasive parameters have been reported as surrogates for this complex physiological entity, but none of them has been tested against the gold-standard in this population. Based on this, our main objective is to assess the correlation of imaging derived RV-PA coupling in comparison to the invasive measurement.
CONDITIONS
Official Title
Pressure-Volume Loop Assessment in Valvular Heart Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥ 18 years old)
- Patients with severe structural heart disease meeting at least one of the following: heart failure with moderate-to-severe or severe secondary mitral regurgitation
- At least severe tricuspid regurgitation
- Significant pulmonary valve stenosis and/or regurgitation
You will not qualify if you...
- Patients under legal guardianship or protection
- Pregnant or breastfeeding women
- Vulnerable individuals such as persons deprived of liberty or adults under legal protection
- Contraindications to right heart catheterization including known proximal venous occlusion of the superior or inferior vena cava territory
- Presence of a mobile mass in the right heart chambers
- Significant tricuspid stenosis
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
CHU of NANTES
Nantes, Loire Atlantique, France, 44000
Actively Recruiting
Research Team
R
Robin LE RUZ, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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