Invasive Hemodynamic Study of Structural Heart Diseases: A Monocentric, Non-Randomized Approach

What this Trial Is About

Researchers are evaluating the function of the right ventricle in patients with severe valvular heart disease (VHD). The study focuses on measuring right ventricular to pulmonary artery (RV-PA) coupling, an important aspect of heart function, using invasive conductance catheters, which are considered the gold standard for assessing ventricular physiology. The goal is to compare these invasive measurements with non-invasive imaging methods to find reliable ways to assess RV-PA coupling in conditions such as secondary mitral regurgitation, tricuspid regurgitation, and right-sided structural heart disease. Participants with severe VHD will undergo non-invasive right ventricular volumetric assessments using MRI, CT, and 3D echocardiography. Within 72 hours, they will have an invasive assessment of RV-PA coupling during routine right heart catheterization (RHC), either before surgery or during a transcatheter valvular intervention. Echocardiographic images will also be taken during RHC to compare with the invasive data, aiming to validate non-invasive imaging parameters like TAPSE/PASP ratio and RV strain. During the study, participants will have imaging and invasive assessments to gather data on RV function. Researchers will analyze the correlation between invasive measurements and non-invasive echocardiographic parameters collected during RHC. The study will monitor the participants through these procedures, with the primary outcome being the correlation of imaging results with the invasive gold standard. The total participation time includes the imaging assessments and the catheterization within a short timeframe.

Pressure-Volume Loop Assessment in Valvular Heart Disease