Actively Recruiting
The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective Study
Led by Hospices Civils de Lyon · Updated on 2026-04-17
180
Participants Needed
6
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
First described in cardiac surgery, the aortic to radial pressure gradient (ATRAP) is the cause of an underestimation of the aortic pressure with a measure assumed with a radial catheter, and he can concert 1 of 3rd patients. The risks factor well known are small height, previous hypertension, long and difficult surgery, radial artery diameter less than 1.8mm. The ATRAP definition is a pressure difference between radial and femoral (same of the aortic pressure) pressure of 25mmHg on the systolic pressure, or a pressure difference on the mean pressure of 10mmHg, both measures realised by arterial canulation, and with a duration superior than 5 minutes. If this gradient appears in pathophysiological specifics situations, there is a risk of inappropriate administration of vasopressors, with more hospitalisation days, more side effect of vasopressors like an augmentation of myocardial work. The ATRAP is documented in septic shock with a prevalence between 21% and 27%. The ATRAP can appear in shocks, moreover with doses of equivalent norepinephrine of 0.5 µg/kg/min who is use for the definition of refractive shock, the difference between the two pressure is higher if the dose of equivalent norepinephrine is higher than 1µg/kg/min. But the prevalence and risks factors are barely unknowns in this situation. Most of the time, a radial arterial catheter is used for hemodynamic monitoring for his simplicity of utilisation and the lows complications associated. Some medical teams in cardiac surgeries, or in intensive care unit (ICU) for the management of shocks used often radial and femoral arterial catheter. It seems there is no at risk for the utilisation of a radial and femoral arterial canulation. Out of the situation of cardiac surgery, there is a lack of information of the ATRAP, the objective of the study is to evaluate the prevalence of the ATRAP in shock, out of the situation of cardiac surgery.
CONDITIONS
Official Title
The Prevalence of the Aortic to Radial Pressure Gradient in States of Shock, Outside the Context of Cardiac Surgery, a Prospective Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Receiving vasopressor support at or above 0.5 g/kg/min norepinephrine equivalent
- Invasive blood pressure monitoring with both radial and femoral arterial catheters as decided by the physician
- Shock started less than 48 hours before enrollment
- Provided consent to participate
You will not qualify if you...
- Undergoing cardiac surgery perioperatively (from start of surgery to 7 days after)
- Pregnant or breastfeeding
- Major person under protection
- Person deprived of liberty by judicial or administrative decision
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Département d'anesthésie Réanimation Hôpital Cardiologique Louis Pradel/Groupement Hospitalier Est
Bron, France, 69500
Actively Recruiting
2
Hopital Edouard heriot/Groupement hospitalier Centre, service de médecine intensive réanimation
Lyon, France, 69003
Actively Recruiting
3
Hôpital Edouard Heriot/ Groupement hospitalier Centre, service d'anesthésie réanimation
Lyon, France, 69003
Actively Recruiting
4
Hôpital de la Croix-Rousse/Groupement hospitalier Nord, service d'anesthésie réanimation
Lyon, France, 69004
Actively Recruiting
5
Hôpital Saint Joseph Saint Luc
Lyon, France, 69007
Actively Recruiting
6
Centre hospitalier Lyon Sud/Groupement hospitalier Sud, Service d'anesthésie réanimation médecine intensive
Lyon, France, 69495
Actively Recruiting
Research Team
M
Matthias Jacquet-lagreze, Dr
CONTACT
M
Martin Ruste, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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