Study on Hidden Heart Problems in Adults Aged 50 to 75 With Type 2 Diabetes

What this Trial Is About

Researchers are investigating the prevalence and causes of early heart dysfunction in adults with type 2 diabetes T2D. This observational study focuses on adults aged 18 to 75 years who have stable T2D without symptoms of cardiovascular disease. The goal is to better understand heart changes in diabetes, which could lead to new treatment targets. The study will compare 518 adults with T2D to 75 healthy individuals matched by age, gender, and ethnicity. Participants will undergo a thorough heart evaluation using several imaging techniques, including cardiac MRI with spectroscopy, echocardiography, CT coronary calcium scoring, and manganese-enhanced MRI in some cases. They will also have cardiopulmonary exercise testing, 24-hour blood pressure monitoring, and wear an accelerometer watch for 7 days to track physical activity. Blood samples will be collected to analyze health markers and develop a protein signature related to early heart failure. During the study, researchers will assess heart structure, function, and blood flow, measuring things like left ventricular strain and myocardial steatosis. They will track early signs of heart failure over 5 years and examine how heart function relates to exercise capacity. Safety and health will be monitored through these tests and blood work. The total study duration spans several years with periodic assessments to understand heart changes in people with type 2 diabetes.

Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus