Actively Recruiting
Prevalence of Exercise-induced Ventilatory Limitation and Associated Factors in Patients With Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor
Led by University Hospital, Lille · Updated on 2026-04-22
130
Participants Needed
1
Research Sites
67 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Lille
Lead Sponsor
V
Vaincre la Mucoviscidose
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cystic fibrosis is a genetic disorder affecting the entire body and associated with respiratory exacerbations, impaired quality of life and reduced life expectancy. The therapeutic management of cystic fibrosis has been profoundly changed by the recent arrival of a combination of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators, Elexacaftor-Tezacaftor-Ivacaftor (ETI), which improve quality of life, respiratory function and reducing the number of exacerbations. The impact of these treatments on exercise adaptation has not been clearly identified. The main objective is to estimate the prevalence of ventilatory reserve amputation during submaximal exercise testing assessed by the 6-minute walk test (6MWT) in patients with cystic fibrosis treated with ETIs.
CONDITIONS
Official Title
Prevalence of Exercise-induced Ventilatory Limitation and Associated Factors in Patients With Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female
- Adult aged 18 or over
- Diagnosed with cystic fibrosis
- Treated at the CRCM in Lille and Cr�e9teil
- Currently treated with Elexacaftor-Tezacaftor-Ivacaftor (ETI)
- Covered by social security
- Able to understand study requirements, provide written informed consent, and comply with data collection
You will not qualify if you...
- Medical contraindication or inability to perform a stress test according to ERS recommendations
- Exacerbation of cystic fibrosis in the 4 weeks before the first visit
- Pregnant or breastfeeding women
- Administrative reasons
- Persons deprived of their liberty
- Minors or legally protected adults
- Persons who have refused or are unable to give informed consent
- Persons in emergency situations
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital
Lille, France, 59037
Actively Recruiting
Research Team
C
Camille AUDOUSSET, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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