Actively Recruiting
The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients
Led by Indiana University · Updated on 2025-10-23
30
Participants Needed
1
Research Sites
362 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Investigators hypothesize that the recalcitrant nature of ocular GVHD may be related to corneal nerve damage and corneal hypoesthesia. The investigators aim to study the prevalence of corneal hypoesthesia in GVHD patients and its correlation with ocular surface changes.
CONDITIONS
Official Title
The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosis of chronic GVHD based on history of allogeneic HSCT and systemic GVHD in organs other than the eye
- In ocular GVHD patients, dry eye symptoms started after systemic GVHD development; if dry eye started earlier, diagnosis based on 2013 International chronic ocular GVHD criteria
- Ocular GVHD patients must have typical dry eye symptoms with Ocular Surface Disease Index (OSDI) score greater than 13
- Corneal fluorescein staining (CFS) score of 3 or more on the National Eye Institute (NEI) grading scale (0-15)
- Normal control group includes age-matched volunteers with OSDI score 13 or less and CFS score less than 3
- Patients may continue current systemic and ocular medications such as preservative-free artificial tears, Restasis, Xiidra, serum tears, ointment, or scleral contact lens
You will not qualify if you...
- History of herpetic simplex or zoster keratitis
- History of ocular or neurologic surgery (including laser or refractive surgery) within 3 months before enrollment
- History of eye trauma
- Diabetes with signs of peripheral neuropathy
- Active corneal thinning or infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Glick Eye Institute - Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
Research Team
L
Linda Morgan
CONTACT
M
Michele Spriggs
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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