Actively Recruiting
Prevalence, Pathogenesis, and Prognosis of Pulmonary Hypertension in Dialysis Patients
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2026-05-04
70
Participants Needed
1
Research Sites
407 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective multicenter longitudinal study aims to investigate the prevalence, pathogenesis, and prognosis of pulmonary hypertension in patients with end-stage renal disease undergoing chronic hemodialysis. The research seeks to identify specific clinical factors and biomarkers like angiopoietin-2 that contribute to the development of this condition, while evaluating the prognostic value of right ventricular function measured via TAPSE. Participants undergo a standardized screening echocardiogram the day after their intermediate dialysis session to determine the probability of pulmonary hypertension. Those identified as high-risk receive further diagnostic confirmation through right heart catheterization, respiratory function tests, and lung scans to clarify the underlying etiology. The protocol also evaluates the hemodynamic impact of high-flow arteriovenous fistulas and volume overload on pulmonary pressures. Clinical follow-up is conducted at baseline and subsequently at 6, 12, and 24 months to monitor patient outcomes and standardize therapeutic management according to established European guidelines.
CONDITIONS
Official Title
Prevalence, Pathogenesis, and Prognosis of Pulmonary Hypertension in Dialysis Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged between 18 and 75 years
- Patients on stable extracorporeal hemodialysis for at least 6 months
- Dialysis frequency of two or three times per week
- Ability to provide written informed consent
You will not qualify if you...
- WHO functional class IV
- Presence of valvular or congenital heart disease
- Acute infections within the month preceding the cardiological evaluation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, Lombardy, Italy, 27100
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here