Actively Recruiting
Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF
Led by Massachusetts General Hospital · Updated on 2024-12-09
515
Participants Needed
1
Research Sites
325 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
A
Akcea Therapeutics
Collaborating Sponsor
AI-Summary
What this Trial Is About
Recent studies have shown that transthyretin amyloidosis (ATTR) can sometimes cause a type of heart failure where the pumping function of the heart is normal, also known as Heart Failure with Preserved Ejection Fraction (HFpEF) or diastolic heart failure. In this single center diagnostic study, we will evaluate for ATTR in patients with HFpEF in order to to determine how frequently this occurs and how we can predict which heart failure patients may have TTR amyloidosis. Our goal is to identify amyloidosis in heart failure patients earlier so that they can start treatment.
CONDITIONS
Official Title
Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with a confirmed diagnosis of HFpEF.
- Age 65 years old
You will not qualify if you...
- End stage chronic kidney disease on dialysis (CKD stage 5 as defined as eGFR <15mL/min)
- History of Heart Failure with reduced ejection fraction (LVEF <40%) except in acute cases such as decompensation, atrial fibrillation with rapid ventricular response, or heart attack
- Negative 99mTc-pyrophosphate scan within the past year
- Unable to lie down for 15 minutes for the 99mTc-pyrophosphate scan
- Known diagnosis of amyloidosis
- Severe or uncorrected moderate to severe valvular heart disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
A
Abbie Macher, BS
CONTACT
L
Laura Stockhausen, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here