Actively Recruiting
Prevalence and Predictors of Incidental Thyroid Carcinoma in Patients With Graves' Disease Undergoing Thyroidectomy.
Led by Minia University · Updated on 2025-07-17
280
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The prevalence of incidental thyroid cancer (ITC) in Graves' Disease (GD) patients undergoing thyroidectomy appears higher than historically believed, potentially exceeding 10% in large contemporary series, although significant variability exists. The presence of nodules is a strong predictor, while the roles of age, sex, and BMI require clarification. Most ITCs are papillary thyroid microcarcinoma(PTMCs) with generally favorable prognoses, but concerns about aggressiveness persist. The purpose of the present study is to accurately evaluate the prevalence of incidental thyroid carcinoma (ITC), including microcarcinomas, in a prospectively enrolled cohort of patients undergoing total thyroidectomy for Graves' disease, utilizing standardized pathological examination protocols and secondary outcomes including predictors and histopathological characteristics.
CONDITIONS
Official Title
Prevalence and Predictors of Incidental Thyroid Carcinoma in Patients With Graves' Disease Undergoing Thyroidectomy.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older.
- Confirmed diagnosis of Graves' disease based on clinical features and biochemical evidence and/or positive TSH receptor antibody test.
- Indication for total thyroidectomy for Graves' disease, including relapse or persistence after antithyroid drugs, intolerance to antithyroid drugs, preference for surgery over other treatments, large goiter causing symptoms, suspicious thyroid nodules, or moderate to severe active Graves' ophthalmopathy.
- Scheduled for total thyroidectomy (near-total or subtotal thyroidectomy patients excluded).
- Ability and willingness to provide written informed consent.
- Ability to understand study procedures and requirements.
You will not qualify if you...
- Age less than 18 years.
- Previous thyroid surgery.
- Previous neck irradiation.
- Preoperative diagnosis of thyroid malignancy confirmed by fine-needle aspiration cytology.
- Inability to provide informed consent.
- Undergoing thyroidectomy primarily for reasons other than Graves' disease.
- Undergoing less than total thyroidectomy (e.g., lobectomy, subtotal thyroidectomy).
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Minia University Hospital
Minya, Minya Governorate, Egypt, 61519
Actively Recruiting
Research Team
S
Saleh K Saleh, MD
CONTACT
R
Rabeh K Saleh, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here