Actively Recruiting
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Children in the Czech Republic
Led by University Hospital, Motol · Updated on 2026-03-19
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how common symptomatic gastroesophageal reflux disease (GERD) is among children aged 8-9 years and 12-13 years in the Czech Republic. The study aims to distinguish confirmed GERD from related conditions like reflux hypersensitivity and functional pyrosis using a stepwise diagnostic approach. It also explores the impact of symptoms on quality of life and examines potential risk factors linked to pediatric GERD. Participants are recruited through selected schools to reflect national demographics and complete an online questionnaire about reflux symptoms, prior medication use, and demographic information. Children reporting symptoms such as heartburn or regurgitation undergo a structured diagnostic process starting with a 14-day proton pump inhibitor (PPI) trial, followed by upper endoscopy if needed. When endoscopy results are inconclusive, 24-hour pH-impedance monitoring is performed to assess reflux severity and symptom association. Children who undergo diagnostic testing complete a validated quality-of-life questionnaire to assess symptom burden. Data collected include symptom presence, diagnostic outcomes, and epidemiologic factors stored securely for analysis. The study will provide population-based prevalence estimates and support future clinical guidance. Participation involves completing questionnaires and, if indicated, undergoing diagnostic tests at the investigators' institution.
CONDITIONS
Brief Title
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 8 to 9 years or 12 to 13 years
- Ability to attend school
You will not qualify if you...
- Presence of psychomotor impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote survey)
Duration - Approximately 4 to 6 weeks
Participants reporting symptoms suggestive of GERD undergo a structured diagnostic pathway including a 14-day symptom recording before and during a 14-day proton pump inhibitor (PPI) trial. Those without a positive response may undergo upper endoscopy and/or 24-hour pH-impedance monitoring to evaluate reflux burden and symptom association.
1 to 3 visits depending on diagnostic procedures
Duration - Duration of study participation up to study completion
Participants complete a validated pediatric quality-of-life assessment to characterize the functional impact of symptoms across diagnostic categories. Epidemiologic and demographic data are collected for risk factor evaluation.
1 follow-up visit or survey
Trial Site Locations
Total: 1 location
1
Motol University Hospital
Prague, Czechia
Actively Recruiting
Research Team
T
Tereza Lerchova
J
Jana Duskova
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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