Actively Recruiting
Preventing Cognitive Decline by Reducing BP Target Trial
Led by University of Texas Southwestern Medical Center · Updated on 2025-12-03
4000
Participants Needed
1
Research Sites
216 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health \& Hospital System.
CONDITIONS
Official Title
Preventing Cognitive Decline by Reducing BP Target Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- High blood pressure defined by at least one reading with systolic \u2265 130 or diastolic \u2265 80 in the past 24 months
- At least one clinic visit with a primary care provider in the last 24 months
- Ability to write and speak English or Spanish
- 70 years of age or older
- Ability to understand and willing to provide informed consent
- Owns a smartphone
You will not qualify if you...
- Blood pressure consistently below 130/80 mmHg
- Diagnosis of dementia, Alzheimer's disease, or significant neurological disease
- Major and unstable heart disease such as acute heart failure, acute coronary syndrome, or cardiac arrest
- Under 70 years of age
- Inability to write or speak English or Spanish
- Chronic kidney disease stage 5 or end-stage kidney disease
- Currently receiving chemotherapy
- Any conditions considered unsafe or likely to reduce adherence by medical providers
- Expected life expectancy less than one year
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
Research Team
V
Venkatraghavan Sundaram, Ph.D.
CONTACT
M
Miguel Vazquez, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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