Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels.
C F Reynolds, J M Perel, E Frank...
https://pubmed.ncbi.nlm.nih.gov/10450257Completed
Phase Not Applicable
Age: 60Years - 80Years
All Genders
ID00000377
Maintenance Therapies in Late-Life Depression
Led by University of Pittsburgh · Updated on 2013-06-21
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to compare the effectiveness of two doses of nortriptyline in elderly patients whose depression returned after stopping treatment. Nortriptyline is an antidepressant. This study enrolls patients who were treated for depression in an earlier research study and whose depression has returned since stopping treatment. Patients are treated for 4 months to bring the depression under control. Patients are then assigned randomly (like tossing a coin) to receive either the full dose of nortriptyline or half the usual dose of nortriptyline. Patients continue taking nortriptyline for 2 years or until a major depression returns. Throughout the study, patients are monitored for symptoms of depression and other side effects.
CONDITIONS
Official Title
Preventing the Return of Depression in Elderly Patients
Who Can Participate
Age: 60Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
Inclusion Criteria:
-
Patients must have:
Recurrence of major depression while in a maintenance placebo condition in the currently funded maintenance therapy protocol (Study I).
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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