Actively Recruiting
Prevention of CIPN Using Compressive Therapy
Led by Martina Lojova · Updated on 2026-04-17
100
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of treatment with taxanes and platinum-based drugs, significantly impacting the quality of life of oncology patients. Symptoms such as reduced sensitivity and pain may persist even after treatment ends. Research has shown that compression therapy using gloves and stockings effectively reduces the incidence of CIPN, improves patient adherence to treatment, and has no severe side effects. A study at the Chemotherapy Unit of the Comprehensive Oncology Care Clinic, Masaryk Memorial Cancer Institute, will investigate the efficacy of this therapy. Tight-fitting gloves and compression stockings will be used to limit the flow of cytotoxic agents to peripheral areas. Effectiveness will be assessed through quality-of-life questionnaires, hand strength and coordination tests, and laboratory analyses to identify predictive markers of neuropathy. The study aims to enhance CIPN prevention and integrate this method into clinical practice.
CONDITIONS
Official Title
Prevention of CIPN Using Compressive Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-70 years at the time of signing the informed consent.
- Signed informed consent.
- Breast cancer stages I-III.
- ECOG performance status 0-2.
- (Neo)adjuvant treatment with paclitaxel weekly.
You will not qualify if you...
- Metastatic disease.
- History of neuropathy or vasculopathy and its pharmacological treatment.
- Type I or II diabetes.
- Stroke within the last 6 months.
- Prior treatment with taxanes and/or cisplatin derivatives.
- Peripheral arterial ischemia.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Masaryk Memorial Cancer Institute
Brno, Czechia, 60200
Actively Recruiting
Research Team
M
Martina Lojova, Ph.D.
CONTACT
I
Iveta Selingerova, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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